Autophagy is a globally conserved cellular activity that plays a critical role in maintaining
cellular homeostasis through the breakdown and recycling of cellular constituents. In recent …

Introduction: Three-dimensional (3D) collagen scaffold models, due to their ability to mimic
the tissue and organ structure in vivo, have received increasing interest in drug discovery …

The development of 3D cell cultures into self‐organizing organ‐like structures named
organoids provides a model that better reflects in vivo organ physiology and their functional …

Cancer cells often adapt to single-agent treatments with chemotherapeutics. Activation of
alternative survival pathways is a major mechanism of drug resistance. A potential approach …

A major factor for developing new tumor models is to recreate a proper three-dimensional
environment for 3D tumors culture. In this 3D microenvironment, extracellular matrices play …

Metastasis is the main cause of cancer morbidity and mortality. Cancer stem cells (CSCs)
are a rare subpopulation of cancer cells that can drive metastasis. The identification of CSC …

Native intact N-glycopeptide analysis can provide access to the comprehensive
characteristics of N-glycan occupancy, including N-glycosites, N-glycan compositions, and N …

Single-agent drug treatment of KRASmut colorectal cancers is often ineffective because the
activation of compensatory signaling pathways leads to drug resistance. To mimic cyclic …

Spheroids of cancer cells represent a physiologic model of solid tumors for cancer drug
screening. Despite this known benefit, difficulties with generating large quantities of …

A primary reason for chemotherapy failure is chemoresistance, which is driven by various
mechanisms. Multi‑drug resistance (MDR) is one such mechanism that is responsible for …