Current treatment options for advanced and recurrent head and neck squamous cell
carcinoma (HNSCC) enclose radiation and chemo-radiation approaches with or without …

Fibroblasts are an abundant cell type in tumor microenvironments. Activated fibroblasts,
known as carcinoma‐associated fibroblasts (CAFs), interact with cancer cells through …

Multicellular tumor spheroids are a good tool for testing new anticancer drugs, including
those that may target cancer stem cells (CSCs), which are responsible for cancer …

Simple Summary A comparative ultrastructural and flow cytometric analysis of colorectal
cancer-derived spheroids and their mouse xenografts showed that they both contain the …

We present a microfluidic dielectrophoretic-actuated system designed to trap chosen single-
cell and form controlled cell aggregates. A novel method is proposed to characterize the …

Abstract Models using 3D cell culture techniques are increasingly accepted as the most
biofidelic in vitro representations of tissues for research. These models are generated using …

Drug resistance is a major barrier against successful treatments of cancer patients. Various
intrinsic mechanisms and adaptive responses of tumor cells to cancer drugs often lead to …

Hepatocellular carcinoma (HCC) is the fastest-growing cause of cancer-related deaths
worldwide. Chronic inflammation and fibrosis are the greatest risk factors for the …

Tumor microenvironment is a complex niche consisting of cancer cells and stromal cells in a
network of extracellular matrix proteins and various soluble factors. Dynamic interactions …

Cancer has recently been the second leading cause of death worldwide, trailing only
cardiovascular disease. Cancer stem cells (CSCs), represented as tumor-initiating cells …