Objective The aim of the present study was to evaluate the long-term outcome in a sample of
patients with bipolar disorder with severe depression or mixed-state resistant to …

Objective The correct identification of bipolar mixed states (MS) has important implications
for clinical practice. The aim of the study was to define the multidimensional …

OBJECTIVES: The clinical significance of subthreshold mixed states is unclear. This study
investigated the clinical outcomes in participants with bipolar I disorder or schizoaffective …

Os autores apresentam uma sintética revisão da história da doença bipolar, a partir de
Araeteus da Capadócia até os tempos atuais. O conceito moderno de doença bipolar foi …

Introduction: The role of antidepressant drugs in acute and maintenance treatment of bipolar
depression is a matter of debate that cannot be decided from the evidence available in the …

Background: Depression with anger may be more common in bipolar disorders. The aim of
the study was to assess whether major depressive disorder (MDD) with anger could be …

Background: This study examined the prevalence of irritability in patients with bipolar I
disorder during an episode of Diagnostic and Statistical Manual of Mental Disorders, Fourth …

Objective: Unlike dysphoric mania, we are unaware of any formal studies of dysphoric
hypomania (DH). For this reason, DH is not formally recognized by DSM‐IV and ICD‐10 …

Background Mixed states, ie, opposite polarity symptoms in the same mood episode,
question the bipolar/unipolar splitting of mood disorders, and support a spectrum view …

Background Psychomotor agitation (PA) or retardation (PR) during major depressive
episodes (MDEs) have been associated with depression severity in terms of treatment …