Metabolism and ATP levels within the oocyte and adjacent cumulus cells are associated
with quality of oocyte and optimal development of a healthy embryo. Lipid metabolism …

Nuclear receptors (NRs) are transcription factors actively involved in many aspects of human
physiology and pathology, serving as sensors of stimuli, master regulators of downstream …

Cancer is a multi-step process and requires constitutive expression/activation of
transcription factors (TFs) for growth and survival. Many of the TFs reported so far are critical …

OBJECTIVE: To discuss the mechanism of action of selective progesterone receptor
modulators (SPRMs) and summarize the preclinical and clinical efficacy and safety data …

Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer
death in females worldwide. It is accepted that breast cancer is not a single disease, but …

BACKGROUND: Aromatase inhibitors are sometimes used in the treatment of selected
patients with uterine leiomyosarcoma (LMS), but there are few data assessing the efficacy of …

Antiprogestins constitute a group of compounds, developed since the early 1980s, that bind
progesterone receptors with different affinities. The first clinical uses for antiprogestins were …

Background Mifepristone (MF) has been largely used in reproductive medicine due to its
capacity to modulate the progesterone receptor (PR). The study of MF has been expanded …

Antiprogestins constitute a group of compounds, developed since the early 1980s, that bind
progesterone receptors with different affinities. The first clinical uses for antiprogestins were …

The present invention relates to methods of administering compositions comprising a
progesterone receptor antagonist for use in treating estrogen-dependent conditions. The …