Cannabis use disorder (CUD) commonly occurs and carries a notable economic and
functional burden at both individual and societal levels. While there are no clearly …

Suicidality is one of the leading causes of death among young adults in the United States
and represents a significant health problem worldwide. The suicide rate among adolescents …

Deciding whether to forgo a good choice in favour of exploring a potentially more rewarding
alternative is one of the most challenging arbitrations both in human reasoning and in …

Neurons in the lateral hypothalamus expressing the neuropeptide Hypocretin, also known
as orexin, are known critical modulators of arousal stability. However, their role in the …

Impulse control deficits are often found to co-occur with substance use disorders (SUDs). On
the one hand, it is well known that chronic intake of drugs of abuse remodels the brain with …

Neuropharmacological interventions in preclinical translational models of impulsivity have
tremendously contributed to a better understanding of the neurochemistry and neural basis …

Chronic pain and attention-deficit hyperactivity disorder (ADHD) frequently coexist.
However, the common pathology is still unclear. Attenuated noradrenergic endogenous …

Not everyone who uses drugs loses control over their intake, which is a hallmark of
addiction. Although familial risk studies suggest significant addiction heritability, the genetic …

Rationale Attention is compromised in many psychiatric disorders, including attention-
deficit/hyperactivity disorder (ADHD). While dopamine and noradrenaline systems have …

Background Work in humans has shown that impulsivity can be advantageous in certain
settings. However, evidence for so-called functional impulsivity is lacking in experimental …