Horizons in the evolution of aging

T Flatt, L Partridge - BMC biology, 2018 - Springer
Between the 1930s and 50s, evolutionary biologists developed a successful theory of why
organisms age, firmly rooted in population genetic principles. By the 1980s the evolution of …

Evolution of ageing as a tangle of trade-offs: energy versus function

AA Maklakov, T Chapman - Proceedings of the Royal …, 2019 - royalsocietypublishing.org
Despite tremendous progress in recent years, our understanding of the evolution of ageing
is still incomplete. A dominant paradigm maintains that ageing evolves due to the competing …

Reproductive senescence: new perspectives in the wild

JF Lemaître, JM Gaillard - Biological Reviews, 2017 - Wiley Online Library
According to recent empirical studies, reproductive senescence, the decline in reproductive
success with increasing age, seems to be nearly ubiquitous in the wild. However, a clear …

Is antagonistic pleiotropy ubiquitous in aging biology?

SN Austad, JM Hoffman - Evolution, medicine, and public health, 2018 - academic.oup.com
Abstract Lay Summary: An evolutionary mechanism of aging was hypothesized 60 years
ago to be the genetic trade-off between early life fitness and late life mortality. Genetic …

The role of telomeres in the mechanisms and evolution of life-history trade-offs and ageing

AJ Young - … Transactions of the Royal Society B …, 2018 - royalsocietypublishing.org
Evolutionary biology and biomedicine have seen a surge of recent interest in the possibility
that telomeres play a role in life-history trade-offs and ageing. Here, I evaluate alternative …

Sex gap in aging and longevity: can sex chromosomes play a role?

GAB Marais, JM Gaillard, C Vieira, I Plotton… - Biology of sex …, 2018 - Springer
It is well known that women live longer than men. This gap is observed in most human
populations and can even reach 10–15 years. In addition, most of the known super …

The naked mole-rat as a model for healthy aging

K Oka, M Yamakawa, Y Kawamura… - Annual Review of …, 2023 - annualreviews.org
Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-lived rodents with a
maximum life span exceeding 37 years. They exhibit a delayed aging phenotype and …

[HTML][HTML] Motivational shifts in aging monkeys and the origins of social selectivity

L Almeling, K Hammerschmidt, H Sennhenn-Reulen… - Current Biology, 2016 - cell.com
As humans age, they become more selective regarding their personal goals [1] and social
partners [2]. Whereas the selectivity in goals has been attributed to losses in resources (eg …

The expensive germline and the evolution of ageing

AA Maklakov, S Immler - Current Biology, 2016 - cell.com
The trade-off between survival and reproduction is the bedrock of the evolutionary theory of
ageing. The reproductive system regulates ageing of the soma, and removal of germ cells …

An evolutionary perspective on why food overconsumption impairs cognition

MP Mattson - Trends in cognitive sciences, 2019 - cell.com
Brain structures and neuronal networks that mediate spatial navigation, decision-making,
sociality, and creativity evolved, in part, to enable success in food acquisition. Here, I discuss …