In recent years, more and more neurodegenerative diseases, such as ALS, FTLD and AD,
have been found to share a common pathological feature, which is the depletion of TDP-43 …

Extracellular vesicles (EVs) are nanoscale bilayer phospholipid membrane vesicles
released by cells. Contained large molecules such as nucleic acid, protein, and lipid, EVs …

Amyotrophic lateral sclerosis (ALS) is described as a fatal and rapidly progressive
neurodegenerative disorder caused by the degeneration of upper motor neurons in the …

Blood is a rich source of disease biomarkers, which include extracellular vesicles (EVs). EVs
are nanometer-to micrometer-sized spherical particles that are enclosed by a phospholipid …

Information exchange is essential for the brain, where it communicates the physiological and
pathological signals to the periphery and vice versa. Extracellular vesicles (EVs) are a …

TDP-43 is the primary or secondary pathological hallmark of neurodegenerative diseases,
such as amyotrophic lateral sclerosis, half of frontotemporal dementia cases, and limbic age …

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disease and is the most
common adult motor neuron disease. The disease pathogenesis is complex with the …

Extracellular vesicles (EVs), as nano-sized vesicles secreted by almost all cells, have been
recognized as the essential transmitter for cell-to-cell communication and participating in …

Exosomes are small extracellular vesicles well-studied both as cell signaling elements and
as source of highly informative biomarkers, in particular microRNAs. Standard techniques for …

Zebrafish (Danio rerio) are rapidly emerging in biomedicine as promising tools for disease
modelling and drug discovery. The use of zebrafish for neuroscience research is also …