In the human skin, melanocytes are present in the epidermis and hair follicles. The basic
features of these cells are the ability to melanin production and the origin from neural crest …

Melanocyte development provides an excellent model for studying more complex
developmental processes. Melanocytes have an apparently simple aetiology, differentiating …

Increased activity of the epigenetic modifier EZH2 has been associated with different
cancers. However, evidence for a functional role of EZH2 in tumorigenesis in vivo remains …

Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …

Elucidation of the cellular identity of neuronal precursors provides mechanistic insights into
the development and pathophysiology of the nervous system. In the enteric nervous system …

In this Review we summarize our current understanding of the biology of mesenchymal cells
of the intestinal lamina propria focusing mainly on fibroblasts and myofibroblasts. The topics …

The brain originates relatively early in development from differentiated ectoderm that forms a
hollow tube and takes on an exceedingly complex shape with development. The skull is …

The neural crest (NC) is an embryonic stem/progenitor cell population that generates a
diverse array of cell lineages, including peripheral neurons, myelinating Schwann cells, and …

Chimaeras are both monsters of the ancient imagination and a long-established research
tool. Recent advances, particularly those dealing with the identification and generation of …

Schwann cell precursors (SCPs) are multipotent embryonic progenitors covering all
developing peripheral nerves. These nerves grow and navigate with unprecedented …