Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy–a review
Osteoarthritis is a leading cause of pain and disability across the world. With an aging
population its prevalence is likely to further increase. Current accepted medical treatment …
population its prevalence is likely to further increase. Current accepted medical treatment …
Articular cartilage and changes in arthritis: cell biology of osteoarthritis
LJ Sandell, T Aigner - Arthritis research & therapy, 2001 - Springer
The reaction patterns of chondrocytes in osteoarthritis can be summarized in five
categories:(1) proliferation and cell death (apoptosis); changes in (2) synthetic activity and …
categories:(1) proliferation and cell death (apoptosis); changes in (2) synthetic activity and …
[PDF][PDF] The role of the chondrocyte in osteoarthritis
MB Goldring - Arthritis & Rheumatism: Official Journal of the …, 2000 - academia.edu
Osteoarthritis (OA) is a slowly progressive degenerative disease characterized by gradual
loss of articular cartilage. Since the OA lesion is often localized to weight-bearing cartilage …
loss of articular cartilage. Since the OA lesion is often localized to weight-bearing cartilage …
The role of cytokines in cartilage matrix degeneration in osteoarthritis.
SR Goldring, MB Goldring - Clinical Orthopaedics and Related …, 2004 - journals.lww.com
Chondrocytes are the single cellular component of hyaline cartilage. Under physiologic
conditions, they show steady-state equilibrium between anabolic and catabolic activities that …
conditions, they show steady-state equilibrium between anabolic and catabolic activities that …
Osteoarthritis and cartilage: the role of cytokines
MB Goldring - Current rheumatology reports, 2000 - Springer
The pathogenesis of osteoarthritis involves multiple etiologies, including mechanical,
biochemical, and genetic factors that contribute to the imbalance in the synthesis and …
biochemical, and genetic factors that contribute to the imbalance in the synthesis and …
[HTML][HTML] Oxygen and reactive oxygen species in cartilage degradation: friends or foes?
Y Henrotin, B Kurz, T Aigner - Osteoarthritis and cartilage, 2005 - Elsevier
OBJECTIVES: This review is focused on the influence of oxygen and derived reactive
species on chondrocytes aging, metabolic function and chondrogenic phenotype …
species on chondrocytes aging, metabolic function and chondrogenic phenotype …
Association between the abnormal expression of matrix‐degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the …
HI Roach, N Yamada, KSC Cheung… - … : Official Journal of …, 2005 - Wiley Online Library
Objective To investigate whether the abnormal expression of matrix metalloproteinases
(MMPs) 3, 9, and 13 and ADAMTS‐4 by human osteoarthritic (OA) chondrocytes is …
(MMPs) 3, 9, and 13 and ADAMTS‐4 by human osteoarthritic (OA) chondrocytes is …
Collagens—major component of the physiological cartilage matrix, major target of cartilage degeneration, major tool in cartilage repair
T Aigner, J Stöve - Advanced drug delivery reviews, 2003 - Elsevier
Collagens serve important mechanical functions throughout the body and in particular in the
connective tissues. Additionally, collagens exert important functions as cellular …
connective tissues. Additionally, collagens exert important functions as cellular …
Molecular pathology and pathobiology of osteoarthritic cartilage
T Aigner, L McKenna - Cellular and molecular life sciences CMLS, 2002 - Springer
The biochemical properties of articular cartilage rely on the biochemical composition and
integrity of its extracellular matrix. This matrix consists mainly of a collagen network and the …
integrity of its extracellular matrix. This matrix consists mainly of a collagen network and the …
The regulation of chondrocyte function by proinflammatory mediators: prostaglandins and nitric oxide
MB Goldring, F Berenbaum - Clinical Orthopaedics and Related …, 2004 - journals.lww.com
Within the mature articular cartilage matrix, which has no blood or nerve supply,
chondrocytes show little metabolic activity with low turnover of matrix components. Under …
chondrocytes show little metabolic activity with low turnover of matrix components. Under …