Osteoarthritis is a leading cause of pain and disability across the world. With an aging
population its prevalence is likely to further increase. Current accepted medical treatment …

The reaction patterns of chondrocytes in osteoarthritis can be summarized in five
categories:(1) proliferation and cell death (apoptosis); changes in (2) synthetic activity and …

Osteoarthritis (OA) is a slowly progressive degenerative disease characterized by gradual
loss of articular cartilage. Since the OA lesion is often localized to weight-bearing cartilage …

Chondrocytes are the single cellular component of hyaline cartilage. Under physiologic
conditions, they show steady-state equilibrium between anabolic and catabolic activities that …

The pathogenesis of osteoarthritis involves multiple etiologies, including mechanical,
biochemical, and genetic factors that contribute to the imbalance in the synthesis and …

OBJECTIVES: This review is focused on the influence of oxygen and derived reactive
species on chondrocytes aging, metabolic function and chondrogenic phenotype …

Objective To investigate whether the abnormal expression of matrix metalloproteinases
(MMPs) 3, 9, and 13 and ADAMTS‐4 by human osteoarthritic (OA) chondrocytes is …

Collagens serve important mechanical functions throughout the body and in particular in the
connective tissues. Additionally, collagens exert important functions as cellular …

The biochemical properties of articular cartilage rely on the biochemical composition and
integrity of its extracellular matrix. This matrix consists mainly of a collagen network and the …

Within the mature articular cartilage matrix, which has no blood or nerve supply,
chondrocytes show little metabolic activity with low turnover of matrix components. Under …