Inter-organellar communication often takes the form of Ca2+ signals. These Ca2+ signals
originate from the endoplasmic reticulum (ER) and regulate different cellular processes like …

Adrenocortical carcinoma (ACC) is an aggressive cancer characterized by poor survival.
Apart from radical surgery, there is a limited range of therapeutic options and mitotane …

Two different primary malignancies can arise from the adrenal gland: adrenocortical
carcinoma (ACC) from the adrenal cortex and malignant phaeochromocytoma from the …

Adrenocortical carcinoma (ACC) is a rare and in most cases steroid hormone-producing
tumor with variable prognosis. The purpose of these guidelines is to provide clinicians with …

PURPOSE Adrenocortical carcinoma (ACC) is a rare aggressive pediatric malignancy with
distinct biology. Its treatment follows the principles developed for adults; pediatric-specific …

Background Adjuvant treatment with mitotane is commonly used after resection of
adrenocortical carcinoma; however, treatment remains controversial, particularly if risk of …

Objective Adrenocortical carcinoma (ACC) has an aggressive but variable clinical course.
Prognostic stratification based on the European Network for the Study of Adrenal Tumours …

Background Objective response of advanced adrenocortical carcinoma (ACC) to mitotane
and cytotoxic chemotherapy regimen is only~ 20% and early tumor progression is frequent …

Objective Current workup for the pre-operative distinction between frequent adrenocortical
adenomas (ACAs) and rare but aggressive adrenocortical carcinomas (ACCs) combines …

Unlike most cancers, adrenocortical carcinomas (ACCs) are more frequent in women than in
men, but the underlying mechanisms of this sexual dimorphism remain elusive. Here, we …