Flaviviruses are vector-borne RNA viruses that can emerge unexpectedly in human
populations and cause a spectrum of potentially severe diseases including hepatitis …

Despite the recent advances in controlling some viral pathogens, most viral infections still
lack specific treatment. Indeed, the need for effective therapeutic strategies to combat 'old' …

Aims A newly emerged Human Coronavirus (HCoV) is reported two months ago in Wuhan,
China (COVID-19). Until today> 2700 deaths from the 80,000 confirmed cases reported …

Background Currently no effective antiviral therapy has been found to treat COVID-19. The
aim of this trial was to assess if the addition of sofosbuvir and daclatasvir improved clinical …

The global pandemic caused by severe acute respiratory syndrome coronavirus‐2 (SARS‐
CoV‐2), named coronavirus disease 2019, has infected more than 8.9 million people …

Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that now causes epidemics
affecting millions of people on multiple continents. The virus has received global attention …

Background New therapeutic options are urgently needed to tackle the novel coronavirus
disease 2019 (COVID-19). Repurposing existing pharmaceuticals provides an immediate …

Galidesivir (BCX4430) is an adenosine nucleoside analog that is broadly active in cell
culture against several RNA viruses of various families. This activity has also been shown in …

Nucleoside analogs represent the largest class of small molecule-based antivirals, which
currently form the backbone of chemotherapy of chronic infections caused by HIV, hepatitis …

Zika virus (ZIKV) has become a global public health emergency due to its rapidly expanding
range and its ability to cause severe congenital defects such as microcephaly. However …