The World Health Organization estimates that the yearly number of dengue cases averages
390 million. This mosquito-borne virus disease is endemic in over 100 countries and will …

Zika virus (ZIKV) drew worldwide attention when a recent epidemic was linked to fetal
microcephaly. Here we used human embryonic stem cell derived trophoblasts as a model …

Flaviviruses are still a hidden threat to global human safety, as we are reminded by recent
reports of dengue virus infections in Singapore and African-lineage-like Zika virus infections …

The minireview surveys the modification of native nucleosides as a result of which huge
libraries of nucleoside analogs of various structures were synthesized. Particular attention is …

The Zika virus (ZIKV) global epidemic prompted the World Health Organization to declare it
a 2016 Public Health Emergency of International Concern. The overwhelming experience …

Zika virus (ZIKV) causes significant public health concerns because of its association with
congenital malformations, neurological disorders in adults, and, more recently, death …

Fluorine-containing nucleoside analogs (NAs) represent a significant class of the US FDA-
approved chemotherapeutics widely used in the clinic. The incorporation of fluorine into …

We evaluated Sofosbuvir (SOF), the anti-hepatitis C virus prodrug of β-d-2′-deoxy-2′-α-
fluoro-2′-β-C-methyluridine-5′-monophosphate, for potential inhibitory activity against …

Zika virus (ZIKV) is an arthropod-borne flavivirus that causes newborn microcephaly and
Guillian-Barré syndrome in adults. No therapeutics are available to treat ZIKV infection or …

Zika virus (ZIKV), belonging to the Flavivirus family and mainly transmitted by mosquitoes,
causes a variety of adverse outcomes, including Guillain-Barré syndrome, microcephaly …