FDA-approved antiviral agents represent an important class that has attracted attention in
recent years to combat current and future threats of viral pandemics. Fluorine ameliorates …

Japanese encephalitis virus (JEV), a major cause of Japanese encephalitisis, is an
arbovirus that belongs to the genus Flavivirus of the family Flaviviridae. Currently, there is no …

Conclusions: In conclusion, viral population dynamics played a critical role during antiviral
treatment. High population diversity during sofosbuvir treatment led to the selection of …

Background This exploratory study investigated four repurposed anti-infective drug
regimens in outpatients with COVID-19. Methods This phase 2, single centre, randomised …

The recent epidemic of Zika virus (ZIKV) in the Americas and its association with fetal and
neurological complications has shown the need to develop a treatment. Repurposing of …

Abstract Background Flaviviruses such as Zika cause sporadic pandemic outbreaks
worldwide. There is an urgent need for anti-Zika virus (ZIKV) drugs to prevent mother-to …

Zika virus (ZIKV) was first discovered in 1947 in Uganda. ZIKV did not entice much attention
until Brazil hosted the 2016 Summer Olympics Game, where ZIKV attracted a global …

In recent years, the outbreak of infectious disease caused by Zika virus (ZIKV) has posed a
major threat to global public health, calling for the development of therapeutics to treat ZIKV …

Background Zika virus (ZIKV) infection is a global health problem, and its complications,
including congenital Zika syndrome and Guillain-Barré syndrome, constitute a continued …

The emergence and rapid spread of Zika virus (ZIKV) in the Americas has prompted the
development of in vitro and in vivo models to understand several aspects of ZIKV biology …