[PDF][PDF] Sofosbuvir as a potential option for the treatment of COVID-19

A Nourian, H Khalili - Acta Bio Medica: Atenei Parmensis, 2020 - pdfs.semanticscholar.org
Sofosbuvir may be a potential option in the treatment of COVID-19 based on the similarity
between the replication mechanisms of the HCV and the coronavirus. According the limited …

The antimalarial drug amodiaquine possesses anti‐ZIKA virus activities

Y Han, T Mesplède, H Xu, Y Quan… - Journal of medical …, 2018 - Wiley Online Library
Zika virus (ZIKV) outbreak has emerged as a global health threat, particularly in tropical
areas, over the past few years. No antiviral therapy or vaccine is available at present. For …

Molecular docking revealed the binding of nucleotide/side inhibitors to Zika viral polymerase solved structures

AA Elfiky, AM Ismail - SAR and QSAR in Environmental Research, 2018 - Taylor & Francis
A new Zika virus (ZIKV) outbreak started in 2015. According to the World Health
Organization, 84 countries confirmed ZIKV infection. RNA-dependent RNA polymerase …

[HTML][HTML] The discovery of Zika virus NS2B-NS3 inhibitors with antiviral activity via an integrated virtual screening approach

MU Mirza, I Alanko, M Vanmeert, KM Muzzarelli… - European Journal of …, 2022 - Elsevier
With expanding recent outbreaks and a lack of treatment options, the Zika virus (ZIKV) poses
a severe health concern. The availability of ZIKV NS2B-NS3 co-crystallized structures paved …

Current status of therapeutic and vaccine approaches against Zika virus

B Wahid, A Ali, S Rafique, M Idrees - European journal of internal medicine, 2017 - Elsevier
Zika virus (ZIKV) is a global threat because it is spreading at an alarming rate because of its
wider range of transmission routes. The neuroteratogenic nature of ZIKV infection is posing …

Complementary mechanisms potentially involved in the pathology of Zika virus

CR Ojha, M Rodriguez, J Lapierre… - Frontiers in …, 2018 - frontiersin.org
Zika virus (ZIKV) has emerged as a global health threat due to its neuro-teratogenic effect
and wide range of transmission routes. Most recently, ZIKV infection has been linked with …

Drug repurposing for the treatment of COVID-19: Pharmacological aspects and synthetic approaches

PN Batalha, LSM Forezi, CGS Lima, FP Pauli… - Bioorganic …, 2021 - Elsevier
In December 2019, a new variant of SARS-CoV emerged, the so-called acute severe
respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus causes the new coronavirus …

Identification of theaflavin-3, 3'-digallate as a novel Zika virus protease inhibitor

X Cui, R Zhou, C Huang, R Zhang, J Wang… - Frontiers in …, 2020 - frontiersin.org
Mounting evidence indicates that Zika virus (ZIKV) is closely related to neurological
disorders such as microcephaly and Guillain-Barré syndrome. There are currently no …

[HTML][HTML] Therapeutic approaches for Zika virus infection of the nervous system

RPM Abrams, J Solis, A Nath - Neurotherapeutics, 2017 - Elsevier
Zika virus has spread rapidly in the Americas and has caused devastation of human
populations affected in these regions. The virus causes teratogenic effects involving the …

Host and viral mechanisms of congenital Zika syndrome

B Liang, JP Guida, ML Costa, IU Mysorekar - Virulence, 2019 - Taylor & Francis
ABSTRACT In 2015–2016, in the Americas, and especially in northeast Brazil, a significant
number of cases of microcephaly and other congenital brain abnormalities were linked with …