Study design Monocentric, prospective, observational study. Objective The clinical
relevance of bacterial colonization of intervertebral discs is controversial. This study aimed …

Background Degenerative disc disease (DDD) is one of the most important causes of low
back pain (LBP). Programmed death of human nucleus pulposus mesenchymal stem cells …

Low back pain resulting from intervertebral disk degeneration is a cause of substantial
disability and productivity loss. Over the past few years, growing evidence exists which …

Background Although cervical intervertebral disc (IVD) degeneration is closely associated
with neck pain, its cause remains unclear. In this study, an animal model of cervical disc …

Background Because facet joints move with the disc, changes in vertebral bodies occur
simultaneously with progression of degeneration of cervical facet joints. This study …

Introduction Multiple reports of bacterial isolates in human disc tissue have suggested a role
of low-grade infection on intervertebral disc degeneration and modic changes (MC) …

Purpose To analyse the presence of endplate sclerosis in patients with various types of
Modic changes (MCs) and to confirm the results using a rabbit model. Methods Participants …

Study Design. Basic science study. Objective. To illustrate supplemental alpha-2
macroglobulin (α2 M) has beneficial effects on cartilaginous endplates (CEPs) that may slow …

Lumbar intervertebral disc degeneration (IVDD) is the most common cause of low back pain
(LBP). Among all the factors leading to IVDD, lumbar cartilage endplate (LCE) degeneration …

Objective Cartilaginous endplate (CEP) degeneration is the main early manifestations of
intervertebral disc degeneration (IVDD), and is closely related to the oxidative stress. Nrf2 …