Mass spectrometry analysis of human tear fluid biomarkers specific for ocular and systemic diseases in the context of 3P medicine

X Zhan, J Li, Y Guo, O Golubnitschaja - EPMA Journal, 2021 - Springer
Over the last two decades, a large number of non-communicable/chronic disorders reached
an epidemic level on a global scale such as diabetes mellitus type 2, cardio-vascular …

Innovating the concept and practice of two-dimensional gel electrophoresis in the analysis of proteomes at the proteoform level

X Zhan, B Li, X Zhan, H Schlüter, PR Jungblut… - Proteomes, 2019 - mdpi.com
Two-dimensional gel electrophoresis (2DE) is an important and well-established technical
platform enabling extensive top-down proteomic analysis. However, the long-held but now …

CD5L as an extracellular vesicle-derived biomarker for liquid biopsy of lung cancer

ES Choi, HA Faruque, JH Kim, KJ Kim, JE Choi… - Diagnostics, 2021 - mdpi.com
Cancer screening and diagnosis can be achieved by analyzing specific molecules within
serum-derived extracellular vesicles (EVs). This study sought to profile EV-derived proteins …

Quantitative proteomics revealed energy metabolism pathway alterations in human epithelial ovarian carcinoma and their regulation by the antiparasite drug …

N Li, H Li, Y Wang, L Cao, X Zhan - EPMA Journal, 2020 - Springer
Objective Energy metabolism abnormality is the hallmark in epithelial ovarian carcinoma
(EOC). This study aimed to investigate energy metabolism pathway alterations and their …

Mass spectrometry-based proteomics analyses of post-translational modifications and proteoforms in human pituitary adenomas

J Li, X Zhan - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2021 - Elsevier
Pituitary adenoma (PA) is a common intracranial neoplasm, which affects the hypothalamus-
pituitary-target organ axis systems, and is hazardous to human health. Post-translational …

Integration of quantitative phosphoproteomics and transcriptomics revealed phosphorylation-mediated molecular events as useful tools for a potential patient …

D Liu, J Li, N Li, M Lu, S Wen, X Zhan - EPMA Journal, 2020 - Springer
Background Invasiveness is a very challenging clinical problem in nonfunctional pituitary
adenomas (NFPAs), and currently, there are no effective invasiveness-related molecular …

The use of mass spectrometry in a proteome‐centered multiomics study of human pituitary adenomas

N Li, DM Desiderio, X Zhan - Mass Spectrometry Reviews, 2022 - Wiley Online Library
A pituitary adenoma (PA) is a common intracranial neoplasm, and is a complex, chronic, and
whole‐body disease with multicausing factors, multiprocesses, and multiconsequences. It is …

Mass spectrometry‐based mitochondrial proteomics in human ovarian cancers

N Li, X Zhan - Mass Spectrometry Reviews, 2020 - Wiley Online Library
The prominent characteristics of mitochondria are highly dynamic and regulatory, which
have crucial roles in cell metabolism, biosynthetic, senescence, apoptosis, and signaling …

[HTML][HTML] Quantitative analysis of the human ovarian carcinoma mitochondrial phosphoproteome

N Li, S Qian, B Li, X Zhan - Aging (Albany NY), 2019 - ncbi.nlm.nih.gov
To investigate the existence and their potential biological roles of mitochondrial
phosphoproteins (mtPPs) in human ovarian carcinoma (OC), mitochondria purified from OC …

Growth hormone proteoformics atlas created to promote predictive, preventive, and personalized approach in overall management of pituitary neuroendocrine tumors

L Yang, C Li, T Song, X Zhan - EPMA Journal, 2023 - Springer
Human growth hormone (GH) is the indispensable hormone for the maintenance of normal
physiological functions of the human body, including the growth, development, metabolism …