BACKGROUND Infertility is an important side effect of treatments used for cancer and other
non-malignant conditions in males. This may be due to the loss of spermatogonial stem cells …

Spermatogenesis originates from spermatogonial stem cells (SSCs). Development of the
spermatogonial transplantation technique in 1994 provided the first functional assay to …

Mammalian spermatogenesis is a classic adult stem cell–dependent process, supported by
self-renewal and differentiation of spermatogonial stem cells (SSCs). Studying SSCs …

Genetic and epigenetic mechanisms regulate the transition from the totipotent zygote to
pluripotent primitive ectoderm cells in the inner cell mass of mouse blastocysts. These …

Context Young boys treated with high-dose chemotherapy are often confronted with infertility
once they reach adulthood. Cryopreserving testicular tissue before chemotherapy and …

The germ cell lineage originates early in development and undergoes a series of complex
developmental processes that culminate in the generation of fully matured gametes, the …

Spermatogonial stem cells (SSCs) are the foundation for spermatogenesis and, thus,
preservation of a species. Because of stem cell rarity, studying their self-renewal is greatly …

Self-renewal and differentiation of spermatogonial stem cells (SSCs) provide the foundation
for testis homeostasis, yet mechanisms that control their functions in mammals are poorly …

Reactive oxygen species (ROS) generation is implicated in stem cell self-renewal in several
tissues but is thought to be detrimental for spermatogenesis as well as spermatogonial stem …

Spermatogonial stem cells (SSCs) are the only stem cells in the body that transmit genetic
information to the next generation. The long-term propagation of rodent SSCs is now …