Cerebral ischemia is a devastating disease that affects many people worldwide every year.
The neurodegenerative damage as a consequence of oxygen and energy deprivation, to …

Background Galectin-3 acts as a mediator of microglial inflammatory response following
stroke injury. However, it remains unclear whether inhibiting galectin-3 protects against …

Acute ischemic stroke (AIS) induces high level of neutrophils, which correlates inversely with
patient survival. Pyroptosis induced by gasdermin D (GSDMD) has been shown to have an …

Abstract Ethnopharmacological relevance Renshen Shouwu extract (RSSW) is a patented
Traditional Chinese Medicine included in Chinese Pharmacopoeia for neurasthenia …

Inflammasomes are known to contribute to brain damage after acute ischemic stroke (AIS).
TAK1 is predominantly expressed in microglial cells and can regulate the NLRP3 …

Innate immune response is one of our primary defenses against pathogens infection,
although, if dysregulated, it represents the leading cause of chronic tissue inflammation. This …

Acute ischemic stroke is a severe condition that a vessel supplying blood to the brain is
abruptly blocked mostly due to cerebral thrombosis and embolism. There is a dearth of the …

ABSTRACT The microRNA‐155 (miR155) regulates various functions of cells. Dysfunction
or injury of endothelial cells (ECs) plays an important role in the pathogenesis of various …

Intracerebral hemorrhage is the most dangerous complication in tPA thrombolytic therapy for
ischemic stroke, which occurs as a consequence of endothelial cell death at the blood–brain …

Acute ischemic stroke (AIS) is a devastating neurological condition with a lack of
neuroprotective therapeutic options, despite the reperfusion modalities thrombolysis and …