The present review aims to provide a complete and comprehensive summary of current
literature relevant to oxysterols and related diseases. Oxidation of cholesterol leads to the …

The innate immune system is the first line of defense specialized in the clearing of invaders
whether foreign elements like microbes or self-elements that accumulate abnormally …

Amyotrophic lateral sclerosis (ALS), the most common adult‐onset motor neuron disease, is
characterized by the selective degeneration of motor neurons leading to paralysis and …

Oxysterols are derivatives of cholesterol and an important regulator of cholesterol
metabolism, in part due to their role as ligands for nuclear receptors, such as the liver X …

Cholesterol is essential for mammalian cell functions and integrity. It is an important
structural component maintaining the permeability and fluidity of the cell membrane. The …

Abstract The role of 27-hydroxycholesterol (27-OHC) in autoimmune diseases has become
a subject of intense research in recent years. This oxysterol, derived from cholesterol, has …

Liver X Receptors (LXR) alpha and beta are two members of nuclear receptor superfamily
documented as endogenous cholesterol sensors. Following conversion of cholesterol in …

Liver X receptor α (LXRα; also known as NR1H3), an isoform of LXRs, is a member of the
nuclear receptor family of transcription factors and plays essential roles in the transcriptional …

Liver X receptor α (LXRα), a member of the nuclear receptor superfamily, is identified as a
protein activated by ligands that interacts with the promoters of specific genes. It regulates …

Plant-derived sterols, phytosterols, are well known for their cholesterol-lowering activity in
serum and their anti-inflammatory activities. Recently, phytosterols have received …