Lateral inhibition, mediated by Notch signaling, leads to the selection of cells that are
permitted to become neurons within domains defined by proneural gene expression …

The intrinsic link of ferroptosis to neurodegeneration, such as Parkinson's disease and
Alzheimer's disease, has set promises to apply ferroptosis inhibitors for treatment of …

Chlorpyrifos (CPF) is one of the most toxic pesticides in aquatic ecosystem, but its toxicity
mechanisms to fish are still not fully understood. This study examined the toxicity targets of …

Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …

Background Human genetic and genomic studies have supported a strong causal role of
SHANK3 deficiency in autism spectrum disorder (ASD). However, the molecular mechanism …

Complex tissue regeneration involves exquisitely coordinated proliferation and patterning of
adult cells after severe injury or amputation. Certain lower vertebrates such as urodele …

Kabuki syndrome (KS) is a rare multiple congenital anomaly syndrome characterized by
distinctive facial features, global developmental delay, intellectual disability and …

Background MicroRNA (miRNA) encoding genes are abundant in vertebrate genomes but
very few have been studied in any detail. Bioinformatic tools allow prediction of miRNA …

Lead induced neurotoxicity has been extensively investigated. However, the potential
connections between early-life lead exposure and the frequently observed aberrant …

Zebrafish are vertebrate organisms that are of growing interest for preclinical drug discovery
applications. Zebrafish embryos develop most of the major organ systems present in …