Alzheimer's therapeutic development: shifting neurodegeneration to neuroregeneration

MK Sun, DL Alkon - Trends in Pharmacological Sciences, 2024 - cell.com
Abstract Alzheimer's disease (AD), similar to AD-related dementias, is characterized by
impaired/lost neuronal structures and functions due to a long progression of …

The neurotransmitter puzzle of Alzheimer's: Dissecting mechanisms and exploring therapeutic horizons

M Sharma, P Pal, SK Gupta - Brain Research, 2024 - Elsevier
Alzheimer's Disease (AD) represents a complex interplay of neurological pathways and
molecular mechanisms, with significant impacts on patients' lives. This review synthesizes …

The probable role of tissue plasminogen activator/neuroserpin axis in Alzheimer's disease: a new perspective

NH Ali, HM Al-Kuraishy, AI Al-Gareeb… - Acta Neurologica …, 2024 - Springer
Alzheimer's disease (AD) is the most common type of dementia associated with amyloid
beta (Aβ) deposition. Dysfunction of the neuronal clearance pathway promotes the …

Tackling seizures in patients with Alzheimer's disease

M Tombini, M Boscarino… - Expert Review of …, 2023 - Taylor & Francis
Introduction In past years, a possible bidirectional link between epilepsy and Alzheimer's
disease (AD) has been proposed: if AD patients are more likely to develop epilepsy, people …

miR‐107‐5p ameliorates neurological damage, oxidative stress, and immune responses in mice with Alzheimer's disease by suppressing the Toll‐like receptor 4 …

GJ Hu, XY Jiang, SY Du, K Zhang… - The Kaohsiung Journal …, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a progressively debilitating neurodegenerative condition
primarily affecting the elderly. Emerging research suggests that microRNAs (miRNAs) play a …

[HTML][HTML] Effect of sodium L-lactate on bioactive properties of chitosan-hydroxyapatite/polycaprolactone conduits for peripheral nerve tissue engineering

K Nawrotek, M Chyb, J Gatkowska, K Rudnicka… - International Journal of …, 2024 - Elsevier
Biomaterials and synthetic polymers have been widely used to replicate the regenerative
microenvironment of the peripheral nervous system. Chitosan-based conduits have shown …

[HTML][HTML] New BDNF and NT-3 Cyclic Mimetics Concur with Copper to Activate Trophic Signaling Pathways as Potential Molecular Entities to Protect Old Brains from …

A Magrì, B Tomasello, I Naletova, G Tabbì, WRL Cairns… - Biomolecules, 2024 - mdpi.com
A low level of Neurotrophins (NTs), their Tyrosine Kinase Receptors (Trks), Vascular
Endothelial Growth Factors (VEGFs) and their receptors, mainly VEGFR1 and VEGFR2 …

Lactocaseibacillus-deglycosylated isoflavones prevent Aβ 40-induced Alzheimer's disease in a rat model

CF Liu, ZY Young, TW Shih, TM Pan, CL Lee - AMB Express, 2024 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disease, with symptoms
appearing in the cerebral cortex and hippocampus. amyloid β peptide (Aβ) has been shown …

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic …

B Xiao, C Chu, Z Lin, T Fang, Y Zhou… - Neural Regeneration …, 2025 - journals.lww.com
A reduction in adult neurogenesis is associated with behavioral abnormalities in patients
with Alzheimer's disease. Consequently, enhancing adult neurogenesis represents a …

[HTML][HTML] Integrated Genome-Wide Analysis of DNA Methylation and Gene Expression in the Hippocampi of 5xFAD Alzheimer's Disease Mouse Model

S Lee, HJ Lee, JM Chun, B Jung, J Kim… - Journal of Integrative …, 2024 - imrpress.com
Background: DNA methylation forms 5-methylcytosine and its regulation in the hippocampus
is critical for learning and memory. Indeed, dysregulation of DNA methylation is associated …