Harnessing ferroptosis to overcome drug resistance in colorectal cancer: promising therapeutic approaches
X Cheng, F Zhao, B Ke, D Chen, F Liu - Cancers, 2023 - mdpi.com
Simple Summary In the realm of colorectal cancer treatment, drug resistance is a formidable
obstacle. However, a ray of hope emerges in the form of ferroptosis, a unique iron-driven cell …
obstacle. However, a ray of hope emerges in the form of ferroptosis, a unique iron-driven cell …
Inhibition of protein aggregation and endoplasmic reticulum stress as a targeted therapy for α-synucleinopathy
N Siwecka, K Saramowicz, G Galita… - Pharmaceutics, 2023 - mdpi.com
α-synuclein (α-syn) is an intrinsically disordered protein abundant in the central nervous
system. Physiologically, the protein regulates vesicle trafficking and neurotransmitter release …
system. Physiologically, the protein regulates vesicle trafficking and neurotransmitter release …
Multi-tissue transcriptomic and serum metabolomic assessment reveals systemic implications of acute ozone-induced stress response in male Wistar Kyoto rats
Air pollutant exposures have been linked to systemic disease; however, the underlying
mechanisms between responses of the target tissue and systemic effects are poorly …
mechanisms between responses of the target tissue and systemic effects are poorly …
Hypocortisolemic ASIA: a vaccine-and chronic infection-induced syndrome behind the origin of long COVID and myalgic encephalomyelitis
M Ruiz-Pablos, B Paiva, A Zabaleta - Frontiers in Immunology, 2024 - frontiersin.org
Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), long COVID (LC) and
post-COVID-19 vaccine syndrome show similarities in their pathophysiology and clinical …
post-COVID-19 vaccine syndrome show similarities in their pathophysiology and clinical …
[HTML][HTML] Metallothionein: A Comprehensive Review of Its Classification, Structure, Biological Functions, and Applications
R Yang, D Roshani, B Gao, P Li, N Shang - Antioxidants, 2024 - ncbi.nlm.nih.gov
Metallothionein is a cysteine-rich protein with a high metal content that is widely found in
nature. In addition to heavy metal detoxification, metallothionein is well known as a potent …
nature. In addition to heavy metal detoxification, metallothionein is well known as a potent …
[HTML][HTML] MiR-29a efficiently suppresses the generation of reactive oxygen species and α-synuclein in a cellular model of Parkinson's disease by potentially targeting …
Abstract MicroRNA-29a (miR-29a) has been suggested to serve a potential protective
function against Parkinson's disease (PD); however, the exact molecular mechanisms …
function against Parkinson's disease (PD); however, the exact molecular mechanisms …
Neuroprotective Strategies and Cell-Based Biomarkers for Manganese-Induced Toxicity in Human Neuroblastoma (SH-SY5Y) Cells
Manganese (Mn) is an essential heavy metal in the human body, while excess Mn leads to
neurotoxicity, as observed in this study, where 100 µM of Mn was administered to the human …
neurotoxicity, as observed in this study, where 100 µM of Mn was administered to the human …
Metal ion-complexed DNA probe coupled with CRISPR/Cas12a amplification and AuNPs for sensitive colorimetric assay of metallothionein in fish
W Zhou, Y Xiang, J Yang, T Chen - … Acta Part A: Molecular and Biomolecular …, 2024 - Elsevier
The accurate and sensitive detection of metallothionein (MT) is of great significance in the
fields of biomedical, toxicological and environmental sciences. In this work, based on the …
fields of biomedical, toxicological and environmental sciences. In this work, based on the …
[HTML][HTML] Neurotoxicity of manganese via ferroptosis induced by redox imbalance and iron overload
C Wang, H Zhao, Y Liu, M Qu, S Lv, G He… - Ecotoxicology and …, 2024 - Elsevier
Manganese (Mn) is an essential trace element for maintaining bodily functions. Excessive
exposure to Mn can pose serious health risks to humans and animals, particularly to the …
exposure to Mn can pose serious health risks to humans and animals, particularly to the …
Metallothionein expression in the central nervous system in response to chronic heavy metal exposure: possible neuroprotective mechanism
A Navarro-Sempere, P Martínez-Peinado… - Environmental …, 2023 - Springer
It has been reported that volcanoes release several tonnes of mercury per year among other
heavy metals through eruptions, fumaroles, or diffuse soil degassing. Since a high …
heavy metals through eruptions, fumaroles, or diffuse soil degassing. Since a high …