Mechanistic insights into the oxidized low‐density lipoprotein‐induced atherosclerosis

C Khatana, NK Saini, S Chakrabarti… - Oxidative medicine …, 2020 - Wiley Online Library
Dyslipidaemia has a prominent role in the onset of notorious atherosclerosis, a disease of
medium to large arteries. Atherosclerosis is the prime root of cardiovascular events …

[HTML][HTML] Oxidative stress, antioxidants and hypertension

M Amponsah-Offeh, P Diaba-Nuhoho, S Speier… - Antioxidants, 2023 - mdpi.com
As a major cause of morbidity and mortality globally, hypertension remains a serious threat
to global public health. Despite the availability of many antihypertensive medications …

[HTML][HTML] LOX-1: regulation, signaling and its role in atherosclerosis

AJ Kattoor, A Goel, JL Mehta - Antioxidants, 2019 - mdpi.com
Atherosclerosis has long been known to be a chronic inflammatory disease. In addition,
there is intense oxidative stress in atherosclerosis resulting from an imbalance between the …

Lipid peroxidation in atherosclerotic cardiovascular diseases

E Gianazza, M Brioschi… - Antioxidants & redox …, 2021 - liebertpub.com
Significance: Atherosclerotic cardiovascular diseases (ACVDs) continue to be a primary
cause of mortality worldwide in adults aged 35–70 years, occurring more often in countries …

Oleuropein: A natural antioxidant molecule in the treatment of metabolic syndrome

J Ahamad, I Toufeeq, MA Khan… - Phytotherapy …, 2019 - Wiley Online Library
Olive (Olea europaea Linn., Fam. Oleaceae) is commonly known as Zaytoon in
Mediterranean region. Its fruits and oil are essential components of Mediterranean diets …

Effects of PCSK9 targeting: alleviating oxidation, inflammation, and atherosclerosis

E Punch, J Klein, P Diaba‐Nuhoho… - Journal of the …, 2022 - Am Heart Assoc
Characterized as a chronic inflammatory disease of the large arteries, atherosclerosis is the
primary cause of cardiovascular disease, the leading contributor of morbidity and mortality …

[HTML][HTML] Atorvastatin ester regulates lipid metabolism in hyperlipidemia rats via the PPAR-signaling pathway and HMGCR expression in the liver

N Hu, C Chen, J Wang, J Huang, D Yao… - International Journal of …, 2021 - mdpi.com
Atorvastatin ester (Ate) is a structural trim of atorvastatin that can regulate hyperlipidemia.
The purpose of this study was to evaluate the lipid-lowering effect of Ate. Male Sprague …

LOX-1 receptor: A potential link in atherosclerosis and cancer

S Balzan, V Lubrano - Life sciences, 2018 - Elsevier
Altered production of reactive oxygen species (ROS), causing lipid peroxidation and DNA
damage, contributes to the progression of atherosclerosis and cancer. Lectin-like oxidized …

[HTML][HTML] PCSK9 functions in atherosclerosis are not limited to plasmatic LDL-cholesterol regulation

A Luquero, L Badimon, M Borrell-Pages - Frontiers in Cardiovascular …, 2021 - frontiersin.org
The relevance of PCSK9 in atherosclerosis progression is demonstrated by the benefits
observed in patients that have followed PCSK9-targeted therapies. The impact of these …

Targeting LOX‐1 in atherosclerosis and vasculopathy: current knowledge and future perspectives

K Tian, S Ogura, PJ Little, S Xu… - Annals of the New York …, 2019 - Wiley Online Library
Abstract LOX‐1 (lectin‐like oxidized low‐density lipoprotein receptor‐1; also known as
OLR1) is the dominant receptor that recognizes and internalizes oxidized low‐density …