Statistical and integrative system-level analysis of DNA methylation data
AE Teschendorff, CL Relton - Nature Reviews Genetics, 2018 - nature.com
Epigenetics plays a key role in cellular development and function. Alterations to the
epigenome are thought to capture and mediate the effects of genetic and environmental risk …
epigenome are thought to capture and mediate the effects of genetic and environmental risk …
Cell-type deconvolution from DNA methylation: a review of recent applications
Recent advances in cell-type deconvolution approaches are adding to our understanding of
the biology underlying disease development and progression. DNA methylation (DNAm) …
the biology underlying disease development and progression. DNA methylation (DNAm) …
Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion
The metabolic challenges present in tumors attenuate the metabolic fitness and antitumor
activity of tumor-infiltrating T lymphocytes (TILs). However, it remains unclear whether …
activity of tumor-infiltrating T lymphocytes (TILs). However, it remains unclear whether …
[HTML][HTML] Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways
Abstract Patients with H3K27M-mutant diffuse midline glioma (DMG) have no proven
effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the …
effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the …
Pathway enrichment analysis and visualization of omics data using g: Profiler, GSEA, Cytoscape and EnrichmentMap
Pathway enrichment analysis helps researchers gain mechanistic insight into gene lists
generated from genome-scale (omics) experiments. This method identifies biological …
generated from genome-scale (omics) experiments. This method identifies biological …
DMDRMR-Mediated Regulation of m6A-Modified CDK4 by m6A Reader IGF2BP3 Drives ccRCC Progression
Y Gu, S Niu, Y Wang, L Duan, Y Pan, Z Tong, X Zhang… - Cancer research, 2021 - AACR
Abstract Aberrant N 6-methyladenosine (m6A) modification has emerged as a driver of
tumor initiation and progression, yet how long noncoding RNAs (lncRNA) are involved in the …
tumor initiation and progression, yet how long noncoding RNAs (lncRNA) are involved in the …
[HTML][HTML] Genome-wide identification of differentially methylated promoters and enhancers associated with response to anti-PD-1 therapy in non-small cell lung cancer
Although approved programmed cell death protein (PD)-1 inhibitors show durable
responses, clinical benefits to these agents are only seen in one-third of patients in most …
responses, clinical benefits to these agents are only seen in one-third of patients in most …
[HTML][HTML] Immunoediting instructs tumor metabolic reprogramming to support immune evasion
CH Tsai, YM Chuang, X Li, YR Yu, SF Tzeng, ST Teoh… - Cell metabolism, 2023 - cell.com
Immunoediting sculpts immunogenicity and thwarts host anti-tumor responses in tumor cells
during tumorigenesis; however, it remains unknown whether metabolic programming of …
during tumorigenesis; however, it remains unknown whether metabolic programming of …
[HTML][HTML] Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals
Differential DNA methylation in the brain is associated with many psychiatric diseases, but
access to brain tissues is essentially limited to postmortem samples. The use of surrogate …
access to brain tissues is essentially limited to postmortem samples. The use of surrogate …
BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation
The branched-chain amino acid (BCAA) pathway and high levels of BCAA transaminase 1
(BCAT1) have recently been associated with aggressiveness in several cancer entities …
(BCAT1) have recently been associated with aggressiveness in several cancer entities …