[HTML][HTML] Animal models of Klebsiella pneumoniae mucosal infections

L Assoni, AJM Couto, B Vieira, B Milani… - Frontiers in …, 2024 - frontiersin.org
Klebsiella pneumoniae is among the most relevant pathogens worldwide, causing high
morbidity and mortality, which is worsened by the increasing rates of antibiotic resistance. It …

Deciphering the gastrointestinal carriage of Klebsiella pneumoniae

AS Bray, MA Zafar - Infection and Immunity, 2024 - Am Soc Microbiol
Bacterial infections pose a significant global health threat, accounting for an estimated 7.7
million deaths. Hospital outbreaks driven by multi-drug-resistant pathogens, notably …

[HTML][HTML] In vivo single-cell high-dimensional mass cytometry analysis to track the interactions between Klebsiella pneumoniae and myeloid cells

R Calderon-Gonzalez, A Dumigan, J Sá-Pessoa… - PLoS …, 2024 - journals.plos.org
In vivo single-cell approaches have transformed our understanding of the immune
populations in tissues. Mass cytometry (CyTOF), that combines the resolution of mass …

Intestinal carbapenem-resistant Klebsiella pneumoniae undergoes complex transcriptional reprogramming following immune activation

C David, A Czauderna, L Cheng, M Lagune… - Gut …, 2024 - Taylor & Francis
Carbapenem-resistant Klebsiella pneumoniae (CR-Kp) is a significant threat to public health
worldwide. The primary reservoir for CR-Kp is the intestinal tract. There, the bacterium is …

No fitness cost entailed by type VI secretion system synthesis, assembly, contraction, or disassembly in enteroaggregative Escherichia coli

B Taillefer, JF Giraud, E Cascales - Journal of Bacteriology, 2023 - Am Soc Microbiol
Polymicrobial communities are shaped by beneficial and antagonistic interactions between
the different species. One of the key players for competition is the type VI secretion system, a …

Navigating ESKAPE Pathogens: Considerations and Caveats for Animal Infection Models Development

H Yu, Y Xu, S Imani, Z Zhao, S Ullah… - ACS Infectious …, 2024 - ACS Publications
The misuse of antibiotics has led to the global spread of drug-resistant bacteria, especially
multi-drug-resistant (MDR) ESKAPE pathogens (Enterococcus faecium, Staphylococcus …

Genome-wide screens reveal shared and strain-specific genes that facilitate enteric colonization by Klebsiella pneumoniae

BH Cheung, A Alisoltani, TJ Kochan, M Lebrun-Corbin… - Mbio, 2023 - Am Soc Microbiol
Gastrointestinal (GI) colonization by Klebsiella pneumoniae is a risk factor for subsequent
infection as well as transmission to other patients. Additionally, colonization is achieved by …

Virulent Klebsiella pneumoniae ST11 clone carrying blaKPC and blaNDM from patients with and without COVID-19 in Brazil

MIS Pimentel, EMB Beltrão… - Journal of Applied …, 2024 - academic.oup.com
Aims Investigated and compared the occurrence of virulence genes fimH, mrkD, irp2, entB,
cps, rmpA, and wabG, resistance genes bla KPC and bla NDM, and the genetic variability …

[HTML][HTML] Outcomes of 23 patients diagnosed with New Delhi metallo-beta-lactamase (NDM)-producing Klebsiella pneumoniae infection treated with ceftazidime …

A Guzek, Z Rybicki, D Tomaszewski… - European Journal of …, 2024 - Springer
Purpose Amongst all etiologic hospital-acquired infection factors, K. pneumoniae strains
producing New Delhi metallo-β-lactamase (KP-NDM) belong to pathogens with the most …

Genome-Wide Identification of Shared and Strain-Specific Factors Necessary for Klebsiella pneumoniae Enteric Colonization

BH Cheung - 2023 - search.proquest.com
Gastrointestinal (GI) colonization by Klebsiella pneumoniae is a risk factor for subsequent
infection as well as transmission to other patients. Additionally, colonization is achieved by …