Toward merging untargeted and targeted methods in mass spectrometry-based metabolomics and lipidomics
Advances in mass spectrometry (MS) and data processing have led to discoveries in
regulation of cellular metabolism by using metabolomics and lipidomics approaches. 1, 2 …
regulation of cellular metabolism by using metabolomics and lipidomics approaches. 1, 2 …
Ion mobility mass spectrometry in the omics era: Challenges and opportunities for metabolomics and lipidomics
G Paglia, AJ Smith, G Astarita - Mass Spectrometry Reviews, 2022 - Wiley Online Library
Researchers worldwide are taking advantage of novel, commercially available,
technologies, such as ion mobility mass spectrometry (IM‐MS), for metabolomics and …
technologies, such as ion mobility mass spectrometry (IM‐MS), for metabolomics and …
Altered cardiac energetics and mitochondrial dysfunction in hypertrophic cardiomyopathy
S Ranjbarvaziri, KB Kooiker, M Ellenberger, G Fajardo… - Circulation, 2021 - Am Heart Assoc
Background: Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by
the effects of individual gene variants on sarcomeric protein biomechanics. At the cellular …
the effects of individual gene variants on sarcomeric protein biomechanics. At the cellular …
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight
INTRODUCTION To date, 559 humans have been flown into space, but long-duration (> 300
days) missions are rare (n= 8 total). Long-duration missions that will take humans to Mars …
days) missions are rare (n= 8 total). Long-duration missions that will take humans to Mars …
[HTML][HTML] Longitudinal multi-omics of host–microbe dynamics in prediabetes
Type 2 diabetes mellitus (T2D) is a growing health problem, but little is known about its early
disease stages, its effects on biological processes or the transition to clinical T2D. To …
disease stages, its effects on biological processes or the transition to clinical T2D. To …
[HTML][HTML] Molecular choreography of acute exercise
Acute physical activity leads to several changes in metabolic, cardiovascular, and immune
pathways. Although studies have examined selected changes in these pathways, the system …
pathways. Although studies have examined selected changes in these pathways, the system …
A longitudinal big data approach for precision health
SM Schüssler-Fiorenza Rose, K Contrepois… - Nature medicine, 2019 - nature.com
Precision health relies on the ability to assess disease risk at an individual level, detect early
preclinical conditions and initiate preventive strategies. Recent technological advances in …
preclinical conditions and initiate preventive strategies. Recent technological advances in …
[HTML][HTML] Metabolic dynamics and prediction of gestational age and time to delivery in pregnant women
Metabolism during pregnancy is a dynamic and precisely programmed process, the failure
of which can bring devastating consequences to the mother and fetus. To define a high …
of which can bring devastating consequences to the mother and fetus. To define a high …
Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation
Recent advances highlight a pivotal role for cellular metabolism in programming immune
responses. Here, we demonstrate that cell-autonomous generation of nicotinamide adenine …
responses. Here, we demonstrate that cell-autonomous generation of nicotinamide adenine …
Challenges and emergent solutions for LC‐MS/MS based untargeted metabolomics in diseases
In the past decade, advances in liquid chromatography‐mass spectrometry (LC‐MS) have
revolutionized untargeted metabolomics analyses. By mining metabolomes more deeply …
revolutionized untargeted metabolomics analyses. By mining metabolomes more deeply …