Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease

EL Konrath, CS Passos, LC Klein-Júnior… - Journal of Pharmacy …, 2013 - academic.oup.com
Objectives The inhibition of acetylcholinesterase (AChE), the key enzyme in the breakdown
of acetylcholine, is currently the main pharmacological strategy available for Alzheimer's …

Direct Synthesis of Protoberberine Alkaloids by Rh‐Catalyzed C− H Bond Activation as the Key Step

J Jayakumar, CH Cheng - Chemistry–A European Journal, 2016 - Wiley Online Library
A one‐pot reaction of substituted benzaldehydes with alkyne–amines by a Rh‐catalyzed C−
H activation and annulation to afford various natural and unnatural protoberberine alkaloids …

Antioxidant, physiological activities, and acetylcholinesterase inhibitory activity of Portulaca oleracea extracts with different extraction methods

YR Kwon, SM Cho, SP Hwang, GM Kwon… - Journal of the Korean …, 2014 - koreascience.kr
The physiological properties of 70% ethanol extracts from Portulaca oleracea with different
extraction methods (reflux extraction, RE; autoclave extraction, AE; low temperature high …

Study on the discrimination between Corydalis Rhizoma and its adulterants based on HPLC-DAD-Q-TOF-MS associated with chemometric analysis

X Zheng, W Zheng, J Zhou, X Gao, Z Liu, N Han… - … of Chromatography B, 2018 - Elsevier
Abstract Corydalis Rhizoma (Yanhuso), is a crucial antianalgesic Traditional Chinese
Medicine in clinic. Its adulterants (Northeast Yanhusuo), which are also from Corydalis and …

Inverting the regioselectivity of the berberine bridge enzyme by employing customized fluorine‐containing substrates

V Resch, H Lechner, JH Schrittwieser… - … A European Journal, 2012 - Wiley Online Library
Fluorine is commonly applied in pharmaceuticals to block the degradation of bioactive
compounds at a specific site of the molecule. Blocking of the reaction center of the enzyme …

磐安延胡索的化学成分研究

杨鑫宝, 刘扬子, 杨秀伟, 刘建勋 - 中草药, 2013 - cqvip.com
目的研究道地产区磐安延胡索Corydalis Rhizoma 的化学成分. 方法采用硅胶, Sephadex LH-20
等柱色谱方法进行分离纯化, 通过化合物的理化性质和谱学数据鉴定其结构. 结果从延胡索95 …

Antioxidant properties and effects of aporphine alkaloids and their phenanthrene seco-isomers on acetylcholinesterase activity

SS Khizrieva, SN Borisenko, EV Maksimenko… - Russian Journal of …, 2022 - Springer
Model phenanthrene seco-alkaloids (seco-glaucine and seco-boldine) obtained in the
medium of subcritical water (SBW) from plant aporphine alkaloids have been studied for the …

[PDF][PDF] Tryptophan-derived Alkaloids from Hedera rhombea Fruits and Their Butyrylcholinesterase Inhibitory Activity

MT Ha, SE Park, JA Kim, MH Woo, JS Choi… - Natural Product …, 2022 - e-nps.or.kr
Abstract Alzheimer's disease (AD) is the most common age-related neurodegenerative
disease in industrialized countries. It is estimated that about 47 million people living with …

[HTML][HTML] Антиоксидантные свойства и эффекты апорфиновых алкалоидов и их фенантреновых секо-изомеров на ацетилхолинэстеразную активность

СС Хизриева, СН Борисенко… - Химия …, 2021 - cyberleninka.ru
Впервые модельные фенантреновые секо-алкалоиды (секо-глауцин и секо-болдин),
полученные в среде субкритической воды СБВ) из растительных апорфиновых …

Cholinesterase inhibitors isolated from the fruits extract of Evodia officinalis

JY Lee, MR Cha, CW Choi, YS Kim… - Korean Journal of …, 2012 - koreascience.kr
Abstract The MeOH extract of Evodiae Fructus exhibited a significant inhibition on the
acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), in a dose dependent …