In neurons, control of microtubule dynamics is required for multiple homeostatic and
regulated activities. Over the past few decades, a great deal has been learned about the role …

This review describes the mechanism of action-inhibition of microtubules-and the most
important mechanisms of resistance for vinca alkaloids, taxanes and epothilones …

Neurodegenerative diseases (NDs) are heterogeneous neurological disorders
characterized by a progressive loss of selected neuronal populations. A significant risk factor …

Background: Twelve separate streams of empirical data make a strong case for cannabis-
induced accelerated aging including hormonal, mitochondriopathic, cardiovascular …

Cells remodel their cytoskeletal networks to adapt to their environment. Here, we analyze
the mechanisms utilized by the cell to tailor its microtubule landscape in response to …

Septins, a family of GTP-binding proteins that assemble into higher order structures,
interface with the membrane, actin filaments and microtubules, and are thus important …

Neuronal morphogenesis is guided by outside-in signals and inside-out mechanisms, which
require spatiotemporal precision. How the intracellular mechanisms of neuronal …

Elp3, the catalytic subunit of the eukaryotic Elongator complex, is a lysine acetyltransferase
that acetylates the C5 position of wobble-base uridines (U34) in transfer RNAs (tRNAs). This …

Autophagy is a biological process that has attracted considerable attention as a target for
novel therapeutics. Recently, nanomaterials (NMs) have been reported to modulate …

Mechanical forces may be generated within a cell due to tissue stiffness, cytoskeletal
reorganization, and the changes (even subtle) in the cell's physical surroundings. These …