The ubiquitin–proteasome system (UPS) is the major intracellular and non-lysosomal
protein degradation system. Thanks to its unique capacity of eliminating old, damaged …

The majority of critically ill intensive care unit (ICU) patients with severe sepsis develop ICU-
acquired weakness (ICUAW) characterized by loss of muscle mass, reduction in myofiber …

Oxidative stress has been implicated in the etiology and pathobiology of various
neurodegenerative diseases. At baseline, the cells of the nervous system have the capability …

Hepatic cholesterol overload promotes steatohepatitis. Insufficient understanding of liver
stress defense impedes therapy development. Here, we elucidate the role of stress defense …

Physical activity may offset cognitive decline and dementia, but the molecular mechanisms
by which it promotes neuroprotection remain elusive. In the absence of disease-modifying …

Although excessive lipid accumulation is a hallmark of obesity-related pathologies, some
lipids are beneficial. Oleic acid (OA), the most abundant monounsaturated fatty acid (FA) …

Methods to stimulate protein degradation through the ubiquitin-proteasome system (UPS)
are being investigated as approaches to treat multiple human diseases and delay aging …

Gallbladder cancer (GBC) is a rare but the most malignant type of biliary tract tumor. It is
usually diagnosed at an advanced stage and conventional treatments are unsatisfactory. As …

Cells exposed to proteotoxic stress invoke adaptive responses aimed at restoring
proteostasis. Our previous studies have established a firm role for the transcription factor …

Several studies reported that mitochondrial stress induces cytosolic proteostasis. How
mitochondrial stress activates proteostasis in the cytosol remains unclear. However, the …