The primary regulators of metazoan gene expression are enhancers, originally functionally
defined as DNA sequences that can activate transcription at promoters in an orientation …

Abstract Topologically Associating Domains (TADs) separate vertebrate genomes into
insulated regulatory neighborhoods that focus genome-associated processes. TADs are …

Highlights•Recent work indicates that chromatin compartments can finely segregate
genomic intervals that are 1–2 kb in size.•Evidence both supports and refutes several …

CP190 is a co-factor in many Drosophila architectural proteins, being involved in the
formation of active promoters and insulators. CP190 contains the N-terminal BTB/POZ …

The three-dimensional organization of mammalian chromosomes can regulate transcription.
Whether transcription itself influences genome structure has remained a source of debate …

Drosophila CP190 and CP60 are transcription factors that are associated with centrosomes
during mitosis. CP190 is an essential transcription factor and preferentially binds to …

In mammals, cohesin and CTCF organize the 3D genome into topologically associated
domains (TADs) to regulate communication between cis-regulatory elements. However …

Here we present the generation and characterization of patient-derived organoids (PDOs)
from colorectal cancer patients. PDOs derived from two patients with TP53 mutations were …

The development and function of the immune system are controlled by temporospatial gene
expression programs, which are regulated by cis-regulatory elements, chromatin structure …

While there is a considerable body of knowledge regarding the molecular and structural
biology and biochemistry of archaeal information processing machineries, far less is known …