Diffuse intrinsic pontine glioma (DIPG) is a type of intrinsic brainstem glial tumor that occurs
primarily in the pediatric population. DIPG is initially diagnosed based on clinical symptoms …

Malignant brain tumors rank among the most challenging type of malignancies to manage.
The current treatment protocol commonly entails surgery followed by radiotherapy and/or …

Neoantigen discovery in pediatric brain tumors is hampered by their low mutational burden
and scant tissue availability. Here we develop a proteogenomic approach combining tumor …

The seventh multi-stakeholder Paediatric Strategy Forum focused on chimeric antigen
receptor (CAR) T-cells for children and adolescents with cancer. The development of CAR T …

Simple Summary H3K27M-mutant diffuse midline glioma is a rare childhood cancer
originating in midline brain structures. The H3K27M mutation substitutes an amino acid on …

The advent of chimeric antigen receptor T (CAR‐T) and the burgeoning field of cellular
therapy has revolutionized the treatment of relapsed/refractory leukemia and lymphoma …

Chimeric antigen receptor-engineered T (CAR T) cell therapy has made great progress in
hematological malignancies and resulted in two newly FDA-approved drugs specific for …

Gliomas are highly treatment refractory against immune checkpoint blockade, an
immunotherapeutic modality that revolutionized therapy for many tumors. At the same time …

Over the last decade, immunotherapy has rapidly changed the therapeutic landscape and
prognosis for many hematologic malignancies and adult solid tumors. Despite this success …

High grade gliomas (HGG) comprise a heterogeneous group of brain malignancies with
dismal prognosis. Current standard-of-care includes radiation, chemotherapy, and surgical …