Glycosphingolipids (GSLs) are major amphiphilic glycolipids present on the surface of living
cell membranes. They have important biological functions, including maintaining plasma …

Purpose: Ongoing clinical trials show limited efficacy for Chimeric antigen receptor (CAR) T
treatment for acute myeloid leukemia (AML). The aim of this study was to identify potential …

Chimeric Antigen Receptor (CAR) T cell therapy has recently begun to be used for solid
tumors such as glioblastoma multiforme. Many children with pediatric malignant brain …

Genomic and transcriptional heterogeneity is prevalent among the most common and
aggressive primary brain tumors in children and adults. Over the past 20 years, advances in …

Simple Summary Diffuse intrinsic pontine glioma (DIPG) is a malignant primary glial tumor
that occurs in all age groups but predominates in children and is estimated to account for …

Background Diffuse intrinsic pontine gliomas (DIPGs) are rare and fatal pediatric brainstem
gliomas with no cure. Chimeric antigen receptor (CAR)-engineered natural killer (NK) cells …

In recent years, the incidence of colorectal cancer (CRC) and breast cancer (BC) has
increased worldwide and caused a higher mortality rate due to the lack of selective anti …

Malignant gliomas carry a dismal prognosis. Conventional treatment using chemo-and
radiotherapy has limited efficacy with adverse events. Therapy with genetically engineered T …

Diffuse midline glioma (DMG) is the leading cause of brain tumor-related deaths in children.
DMG typically presents with variable neurologic symptoms between ages 3 and 10 …

Chimeric antigen receptor (CAR) T‐cells treatment demonstrate the increasing and powerful
potential of immunotherapeutic strategies, as seen mainly for hematological malignancies …