Secondary progressive multiple sclerosis: new insights
In most cases, multiple sclerosis (MS) begins with a relapsing-remitting course followed by
insidious disability worsening that is independent from clinically apparent relapses and is …
insidious disability worsening that is independent from clinically apparent relapses and is …
Multiple sclerosis: clinical aspects
J Oh, A Vidal-Jordana, X Montalban - Current opinion in …, 2018 - journals.lww.com
A number of recent advances have been made in the clinical diagnosis and prognostication
of multiple sclerosis patients. Future research will enable the development of more accurate …
of multiple sclerosis patients. Future research will enable the development of more accurate …
Contribution of relapse-independent progression vs relapse-associated worsening to overall confirmed disability accumulation in typical relapsing multiple sclerosis in …
Importance Accumulation of disability in multiple sclerosis may occur as relapse-associated
worsening (RAW) or steady progression independent of relapse activity (PIRA), with PIRA …
worsening (RAW) or steady progression independent of relapse activity (PIRA), with PIRA …
Association of early progression independent of relapse activity with long-term disability after a first demyelinating event in multiple sclerosis
C Tur, P Carbonell-Mirabent, Á Cobo-Calvo… - JAMA …, 2023 - jamanetwork.com
Importance Progression independent of relapse activity (PIRA) is the main event responsible
for irreversible disability accumulation in relapsing multiple sclerosis (MS). Objective To …
for irreversible disability accumulation in relapsing multiple sclerosis (MS). Objective To …
Association of initial disease-modifying therapy with later conversion to secondary progressive multiple sclerosis
JWL Brown, A Coles, D Horakova, E Havrdova… - Jama, 2019 - jamanetwork.com
Importance Within 2 decades of onset, 80% of untreated patients with relapsing-remitting
multiple sclerosis (MS) convert to a phase of irreversible disability accrual termed secondary …
multiple sclerosis (MS) convert to a phase of irreversible disability accrual termed secondary …
Silent progression in disease activity–free relapsing multiple sclerosis
University of California, San Francisco MS … - Annals of …, 2019 - Wiley Online Library
Objective Rates of worsening and evolution to secondary progressive multiple sclerosis
(MS) may be substantially lower in actively treated patients compared to natural history …
(MS) may be substantially lower in actively treated patients compared to natural history …
Serum GFAP and NfL levels differentiate subsequent progression and disease activity in patients with progressive multiple sclerosis
Background and Objectives Neurodegeneration and astrocytic activation are pathologic
hallmarks of progressive multiple sclerosis (MS) and can be quantified by serum …
hallmarks of progressive multiple sclerosis (MS) and can be quantified by serum …
Early use of high-efficacy disease‑modifying therapies makes the difference in people with multiple sclerosis: an expert opinion
M Filippi, MP Amato, D Centonze, P Gallo… - Journal of …, 2022 - Springer
Multiple sclerosis (MS) is a chronic and progressive neurological disease that is
characterized by neuroinflammation, demyelination and neurodegeneration occurring from …
characterized by neuroinflammation, demyelination and neurodegeneration occurring from …
Progression is independent of relapse activity in early multiple sclerosis: a real-life cohort study
E Portaccio, A Bellinvia, M Fonderico, L Pastò… - Brain, 2022 - academic.oup.com
Disability accrual in multiple sclerosis may occur as relapse-associated worsening or
progression independent of relapse activity. The role of progression independent of relapse …
progression independent of relapse activity. The role of progression independent of relapse …
T helper cells: the modulators of inflammation in multiple sclerosis
M Kunkl, S Frascolla, C Amormino, E Volpe, L Tuosto - Cells, 2020 - mdpi.com
Multiple sclerosis (MS) is a chronic neurodegenerative disease characterized by the
progressive loss of axonal myelin in several areas of the central nervous system (CNS) that …
progressive loss of axonal myelin in several areas of the central nervous system (CNS) that …