While gap junctions support the exchange of a number of molecules between neighboring
cells, connexin hemichannels provide communication between the cytosol and the …

Hepatitis C virus (HCV) infection is the major risk factor for liver cirrhosis and hepatocellular
carcinoma (HCC). The mechanisms of HCC initiation, growth, and metastasis appear to be …

Gap junctions (GJ) and hemichannels (HC) formed from the protein subunits called
connexins are transmembrane conduits for the exchange of small molecules and ions …

Gap Junction (GJ) channels, including the most common Connexin 43 (Cx43), have
fundamental roles in excitable tissues by facilitating rapid transmission of action potentials …

Pannexins form channels at the plasma membrane surface that establish a pathway for
communication between the cytosol of individual cells and their extracellular environment …

Continuously increasing understanding of the molecular triggers responsible for the onset of
diseases, paralleled by an equally dynamic evolution of chemical synthesis and screening …

Different pathways contribute to the turnover of connexins, the main structural components of
gap junctions (GJs). The cellular pool of connexins targeted to each pathway and the …

Gap junction channels are composed of two apposing hemichannels (connexons) in the
contiguous cells and provide a direct pathway for electrical and metabolic signaling between …

BACKGROUND & AIMS: In cirrhosis, superimposed inflammation often culminates in acute-
on-chronic liver failure (ACLF) but the mechanism underlying this increased sensitivity is not …

It is nowadays well established that gap junctions are critical gatekeepers of cell
proliferation, by controlling the intercellular exchange of essential growth regulators. In …