International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors
ML Dubocovich, P Delagrange, DN Krause… - Pharmacological …, 2010 - ASPET
The hormone melatonin (5-methoxy-N-acetyltryptamine) is synthesized primarily in the
pineal gland and retina, and in several peripheral tissues and organs. In the circulation, the …
pineal gland and retina, and in several peripheral tissues and organs. In the circulation, the …
Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists
FW Turek, MU Gillette - Sleep medicine, 2004 - Elsevier
Circadian rhythm sleep disorders (CRSDs), whether chronic or transient, affect a broad
range of individuals, including many elderly, those with severe visual impairments, shift …
range of individuals, including many elderly, those with severe visual impairments, shift …
MT1 and MT2 Melatonin Receptors: Ligands, Models, Oligomers, and Therapeutic Potential
Numerous physiological functions of the pineal gland hormone melatonin are mediated via
activation of two G-protein-coupled receptors, MT1 and MT2. The melatonergic drugs on the …
activation of two G-protein-coupled receptors, MT1 and MT2. The melatonergic drugs on the …
From circadian rhythms to clock genes in depression
FW Turek - International clinical psychopharmacology, 2007 - journals.lww.com
Depression, particularly unipolar depression, has often been linked to circadian (ie
approximately 24-h) rhythm abnormalities. The observation that many diverse rhythms are …
approximately 24-h) rhythm abnormalities. The observation that many diverse rhythms are …
Direct Synthesis of 2‐(Aminomethyl) indoles through Copper (I)‐Catalyzed Domino Three‐Component Coupling and Cyclization Reactions
H Ohno, Y Ohta, S Oishi, N Fujii - … Chemie International Edition, 2007 - Wiley Online Library
The indole nucleus is a prominent structural motif found in numerous natural products and
synthetic compounds with important biological activities, and thus considerable attention has …
synthetic compounds with important biological activities, and thus considerable attention has …
Cardioprotective melatonin: translating from proof-of-concept studies to therapeutic use
OC Baltatu, S Senar, LA Campos… - International Journal of …, 2019 - mdpi.com
In this review we summarized the actual clinical data for a cardioprotective therapeutic role
of melatonin, listed melatonin and its agonists in different stages of development, and …
of melatonin, listed melatonin and its agonists in different stages of development, and …
Construction of Nitrogen Heterocycles Bearing an Aminomethyl Group by Copper-Catalyzed Domino Three-Component Coupling− Cyclization
Y Ohta, H Chiba, S Oishi, N Fujii… - The Journal of Organic …, 2009 - ACS Publications
A direct approach to 2-(aminomethyl) indoles by copper-catalyzed domino three-component
coupling− cyclization of 2-ethynylanilines with a secondary amine and aldehyde has been …
coupling− cyclization of 2-ethynylanilines with a secondary amine and aldehyde has been …
N-(Substituted-anilinoethyl)amides: Design, Synthesis, and Pharmacological Characterization of a New Class of Melatonin Receptor Ligands
A novel series of melatonin receptor ligands, characterized by a N-(substituted-anilinoethyl)
amido scaffold, along with preliminary structure–activity relationships (SARs), is presented …
amido scaffold, along with preliminary structure–activity relationships (SARs), is presented …
Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines
Molecular superposition models guided the design of novel melatonin receptor ligands
characterized by a 2-acylaminomethyltetrahydroquinoline scaffold. Starting from the …
characterized by a 2-acylaminomethyltetrahydroquinoline scaffold. Starting from the …
Identification of bivalent ligands with melatonin receptor agonist and fatty acid amide hydrolase (FAAH) inhibitory activity that exhibit ocular hypotensive effect in the …
Activation of melatonin receptors and inhibition of fatty acid amide hydrolase (FAAH) have
both shown potential benefits for the treatment of glaucoma. To exploit the combination of …
both shown potential benefits for the treatment of glaucoma. To exploit the combination of …