Total opioid‐free general anaesthesia can improve postoperative outcomes after surgery, without evidence of adverse effects on patient safety and pain management …

A Olausson, CJ Svensson, P Andréll… - Acta …, 2022 - Wiley Online Library
Background Opioid‐based treatment is used to manage stress responses during surgery
and postoperative pain. However, opioids have both acute and long‐term side effects …

Current issues in the use of opioids for the management of postoperative pain: a review

PE Macintyre, J Quinlan, N Levy, DN Lobo - JAMA surgery, 2022 - jamanetwork.com
Importance Uncontrolled and indiscriminate prescribing of opioids has led to an opioid crisis
that started in North America and spread throughout high-income countries. The aim of this …

Balanced Opioid-free Anesthesia with Dexmedetomidine versus Balanced Anesthesia with Remifentanil for Major or Intermediate Noncardiac Surgery: The …

H Beloeil, M Garot, G Lebuffe, A Gerbaud, J Bila… - …, 2021 - pubs.asahq.org
Background It is speculated that opioid-free anesthesia may provide adequate pain control
while reducing postoperative opioid consumption. However, there is currently no evidence …

Impact of opioid-free anaesthesia on postoperative nausea, vomiting and pain after gynaecological laparoscopy-A randomised controlled trial

C Massoth, J Schwellenbach, K Saadat-Gilani… - Journal of clinical …, 2021 - Elsevier
Study objective Opioid-free anaesthesia may enhance postoperative recovery by reducing
opioid-related side effects such as nausea, hyperalgesia or tolerance. The objective was to …

Opioids and public health: the prescription opioid ecosystem and need for improved management

ED Kharasch, JD Clark, JM Adams - Anesthesiology, 2022 - pubs.asahq.org
While US opioid prescribing has decreased 38% in the past decade, opioid deaths have
increased 300%. This opioid paradox is poorly recognized. Current approaches to opioid …

Association of intraoperative opioid administration with postoperative pain and opioid use

LASC Mercado, R Liu, KM Bharadwaj, JJ Johnson… - JAMA …, 2023 - jamanetwork.com
Importance Opioids administered to treat postsurgical pain are a major contributor to the
opioid crisis, leading to chronic use in a considerable proportion of patients. Initiatives …

Perioperative opioids, the opioid crisis, and the anesthesiologist

DB Larach, JM Hah, CM Brummett - Anesthesiology, 2022 - pubs.asahq.org
Perioperative Opioids, the Opioid Crisis, and the Anesthesiologist | Anesthesiology |
American Society of Anesthesiologists Skip to Main Content Advertisement Umbrella Alt …

The pain management of trauma patients in the emergency department

A Fabbri, A Voza, A Riccardi, S Serra… - Journal of Clinical …, 2023 - mdpi.com
The vast majority of injured patients suffer from pain. Systematic assessment of pain on
admission to the emergency department (ED) is a cornerstone of translating the best …

Opioid-free anesthesia: time to regain our balance

ED Kharasch, JD Clark - Anesthesiology, 2021 - pubs.asahq.org
Changes in clothing, automobiles, and restaurants follow popular trends and are often
periodic and cyclical. Ideally, medical change is driven not by fashion but instead by …

Opioid-free anesthesia compared to opioid anesthesia for lung cancer patients undergoing video-assisted thoracoscopic surgery: a randomized controlled study

G An, Y Zhang, N Chen, J Fu, B Zhao, X Zhao - PLoS One, 2021 - journals.plos.org
Background Reducing intra-operative opioid consumption benefits patients by decreasing
postoperative opioid-related adverse events. We assessed whether opioid-free anesthesia …