Recent investigations indicate that hematopoiesis is coregulated by innate immunity signals
and by pathways characteristic of the activation of innate immunity cells that also operate in …

Classic Hodgkin lymphoma (cHL) is characterized by a few tumor cells surrounded by a
protective, immunosuppressive tumor microenvironment composed of normal cells that are …

Ischemia-reperfusion (I/R) injury (IRI), which involves inflammation, vascular permeability,
and edema, remains a major challenge after lung transplantation. Pannexin-1 (Panx1) …

Myeloid-derived suppressor cells (MDSCs) can subdue inflammation. In mice with acute
graft-versus-host disease (GVHD), donor MDSC infusion enhances survival that is only …

Since purinergic signaling was discovered in the early 1970s, it has been shown that
extracellular nucleotides, and their derivative nucleosides, are released in a regulated or …

Purinergic receptor-7 (P2X7R) signaling controls Th17 and Th1 generation/differentiation,
while NOD-like receptor P3 (NLRP3) acts as a Th2 transcriptional factor. Here, we …

Objective Embryo implantation needs a reciprocal interaction between competent embryo
and receptive endometrium. Adenosine triphosphate (ATP) produced by stressed or injured …

Hematologic malignancies comprise a considerable part of cancers with high mortality at
any age. Since the introduction of hematopoietic stem cell transplantation (HSCT), the …

Neuropathic pain (NP) has become a serious global health issue and a huge clinical
challenge without available effective treatment. P2 receptors family is involved in pain …

Acute graft-versus-host disease (GvHD) causes high mortality in patients undergoing
allogeneic hematopoietic cell transplantation. An early event in the classical pathogenesis of …