Background Vancomycin is commonly used to treat gram-positive bacterial infections in the
paediatric population, but dosing can be challenging. Population pharmacokinetic (popPK) …

Vancomycin is a fundamental antibiotic in the management of severe Gram‐positive
infections. Inappropriate vancomycin dosing is associated with therapeutic failure, bacterial …

In the last years, there has been a tremendous increase in the incidence of bacterial
infections due to resistant strains, especially multi-drug resistant Gram-negative bacilli. In …

Aims Vancomycin is frequently used in critically ill children in whom the drug
pharmacokinetics are significantly altered as a result of changes in renal clearance and …

Clinical vancomycin (Van) treatment is administered over a prolonged period to achieve a
sustained therapeutic effect. Accurate, rapid, and continuous Van detection is an unmet …

Background The incidence of nephrotoxicity among vancomycin-treated neonates has been
reported to range from 2% to 20%. These widely varying estimates have led to confusion …

Abstract Background and Objective Critically ill children exhibit altered pharmacokinetic
parameters of vancomycin, mainly due to altered renal excretion and volume of distribution …

Background: Vancomycin therapeutic drug monitoring (TDM) is necessary for effective and
safetherapy. The aim of the this paper was to develop a specific and robust ultra high …

This work is dedicated to the memory of Hartmut Derendorf (1953–2020), a pioneer of
modern pharmacokinetics and valued mentor of this project. Objectives: Septic …

Value-added pharmacy services encompass traditional and emerging services provided by
pharmacists to individual and entire populations of persons increasingly under the auspices …