Colorectal cancer (CRC) can be resistant to platinum drugs, possibly through ferroptosis
suppression, albeit the need for further work to completely understand this mechanism. This …

Purpose This study evaluated whether an addition of simvastatin to chemotherapy improves
survival in ever-smokers with extensive disease (ED)–small cell lung cancer (SCLC) …

Background Despite therapeutic advances, the prognosis of pancreatic ductal
adenocarcinoma (PDAC) remains extremely poor. Metabolic reprogramming is increasingly …

Dyslipidemia is a major cause of cardiovascular diseases which represent a leading cause
of death in humans. Diverse immune cells are known to be involved in the pathogenesis of …

Metastatic melanoma has a very poor prognosis. Statins, 3-hydroxy-3-methyl-glutaryl-
coenzyme A reductase (HMGCR) inhibitors, are cholesterol-lowering agents with a potential …

Breast cancer affects one in eight women during their lifetime. Although diagnostic and
therapeutic options have improved, recurrence, metastasis, and therapeutic resistance …

Chemotherapy still plays a central role in the treatment of cancer. However, it is often
accompanied by off-target effects that result in severe side-effects and development of drug …

Background: Pancreatic cancer (PC) is a type of cancer with a high incidence and case-
fatality rate. Objective: This study aimed to evaluate the role of statins in preventing mortality …

Tumor cells reprogram their metabolism, including glucose, glutamine, nucleotide, lipid, and
amino acids to meet their enhanced energy demands, redox balance, and requirement of …

Simple Summary Statins are medicines used to treat patients with high lipid levels
(hyperlipidemia). Studies have reported that patients undergoing statin therapy are at …