Dietary fibre has long been established as a nutritionally important, health-promoting food
ingredient. Modern dietary practices have seen a significant reduction in fibre consumption …

Natural products obtained in dietary components may aid the prevention and treatment of a
variety of diseases. Reports in the scientific literature have demonstrated that the …

Nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH) has
reached epidemic proportions with no pharmacological therapy approved. Lower circulating …

Aging is a complex phenomenon characterized by the progressive loss of tissue and organ
function. The oxidative-stress theory of aging postulates that age-associated functional …

The prevalence of the metabolic syndrome, a cluster of cardiovascular risk factors
associated with obesity and insulin resistance, is dramatically increasing in Western and …

Hepatocellular carcinoma (HCC), the major form of primary liver cancer, is one of the most
deadly human cancers. The pathogenesis of HCC is frequently linked with continuous …

Endocannabinoids and cannabinoid CB1 receptors are known to play a generalized role in
energy homeostasis. However, clinical trials with the first generation of CB1 blockers, now …

Epidemiological studies indicate that overweight and obesity are associated with increased
cancer risk. To study how obesity augments cancer risk and development, we focused on …

The role of adipose tissue insulin resistance in the pathogenesis of nonalcoholic fatty liver
disease (NAFLD) remains unclear. To evaluate this, we measured in 207 patients with …

NASH is becoming increasingly common worldwide because of the growing global
prevalence of obesity and consequently NAFLD. Unfortunately, the mechanism of …