Tryptophan (Tryp) is an essential amino acid and the precursor of several neuroactive
compounds within the central nervous system (CNS). Tryp metabolism, the common …

Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a
disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is …

Tryptophan (Trp) is an essential amino acid that can be metabolized via endogenous and
exogenous pathways, including the Kynurenine Pathway, the 5-Hydroxyindole Pathway …

Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex
and debilitating illness with a significant global prevalence, affecting over 65 million …

Tryptophan metabolism along the kynurenine pathway is of central importance for the
immune function. It prevents hyperinflammation and induces long-term immune tolerance …

Simple Summary The molecular mechanisms of Charcot–Marie–Tooth (CMT) disease,
involving impaired vitamin metabolism and/or actions, are considered in light of the potential …

Ochratoxin A (OTA), commonly found in various foods, significantly impacts the health of
humans and animals, especially their kidneys. Our study explores OTA's effects on the gut …

Dysregulation of the kynurenine pathway (KP) is believed to play a significant role in
neurodegenerative and cognitive disorders. While some evidence links the KP to myalgic …

Up to 10 million people per annum experience traumatic brain injury (TBI), 80–90% of which
are categorized as mild. A hit to the brain can cause TBI, which can lead to secondary brain …

It has been four years since long COVID—the protracted consequences that survivors of
COVID-19 face—was first described. Yet, this entity continues to devastate the quality of life …