Prodrugs have emerged as a major strategy for addressing clinical challenges by improving
drug pharmacokinetics, reducing toxicity, and enhancing treatment efficacy. The emergence …

Cancer is one of the most common causes of death. So, its lethal effect increases with time.
Near about hundreds of cancers are known in humans. Cancer treatment is done to cure or …

As heavy-metal-based nanoscale metal–organic frameworks (nMOFs) are excellent
radiosensitizers for radiotherapy via enhanced energy deposition and reactive oxygen …

Confining the protein degradation activity of proteolysis-targeting chimera (PROTAC) to
cancer lesions ensures precision treatment. However, it still remains challenging to precisely …

Abstract Proteolysis Targeting Chimeras (PROTACs) represent a promising therapeutic
modality to address undruggable and resistant issues in drug discovery. However, potential …

The proteolysis targeting chimeras (PROTACs) approach has attracted extensive attention in
the past decade, which represents an emerging therapeutic modality with the potential to …

Proteolysis-targeting chimera (PROTAC) technology represents a novel and promising
modality for targeted protein degradation with transformative implications for the clinical …

Protein degradation mediated by the proteolysis-targeting chimera (PROTAC) has emerged
as an efficient strategy to accurately control intracellular protein levels. However, the …

Proteolysis-targeting chimera (PROTAC) is emerging as a new strategy to degrade target
proteins in a precise way by taking advantage of the cellular ubiquitin-proteasome system …

Radiotherapy is a mainstream modality for breast cancer treatment that employs ionizing
radiation (IR) to damage tumor cell DNA and elevate ROS stress, which demonstrates …