In land mammals, a major task of the kidney is to reabsorb water to allow survival in a dry
environment. Water conservation is enhanced by the renal medulla, which concentrates the …

Work during the past several years has produced new insights into many aspects of the cell
biology of ischemic injury to the tubulointerstitium. The major processes are conveniently …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

For more than 15 years, there has been an ongoing debate regarding the nephron segment
(s) most severely injured in acute renal failure (ARF) induced by an ischemic or toxic insult …

BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal
tubule cells. Background Proximal tubule epithelial cells (PTEC) play a central role in the …

Since human acute renal failure (ARF) is frequently the result of multiple rather than single
insults, we used a combination of treatments to induce ARF in rats. Uninephrectomized, salt …

The promotion of cell survival and regeneration in acute renal failure (ARF) is important for
restitution of renal function. This study analyzes the temporal and spatial relationship …

Background Increasing evidence indicates that renal recovery from AKI stems from
dedifferentiation and proliferation of surviving tubule epithelial cells. Both EGF receptor …

To determine the role of epidermal growth factor receptor (EGFR) activation in renal
functional and structural recovery from acute kidney injury (AKI), we generated mice with a …

Although ischemia-reperfusion of mouse kidney is known to cause severe renal failure due
to tubular cell death, the exact cellular mechanism responsible for this phenomenon is not …