Premature activation of digestive enzymes in the pancreas has been linked to development
of pancreatitis for more than a century. Recent development of novel models to study the …

The endoplasmic reticulum (ER) is a multifunctional organelle required for lipid biosynthesis,
calcium storage, and protein folding and processing. A number of physiological and …

Abstract Background Approximately 8–9% of the world's population is affected by
autoimmune diseases, and yet the mechanism of autoimmunity trigger is largely …

Elevated pressure in the pancreatic gland is the central cause of pancreatitis following
abdominal trauma, surgery, endoscopic retrograde cholangiopancreatography, and …

Drug-free macromolecular therapeutics are promising alternatives to traditional drugs.
Nanomedicines with multiple organelles targeting can potentially increase the efficacy …

Key points This work confirms previous reports that CM4620, a small molecule inhibitor of
Ca2+ entry via store operated Ca2+ entry (SOCE) channels formed by stromal interaction …

We have investigated in detail the role of intra-organelle Ca 2+ content during induction of
apoptosis by the oxidant menadione while changing and monitoring the Ca 2+ load of …

Background & Aims Pancreatitis is characterized by acinar cell death and persistent
inflammation. Ferroptosis is a type of lipid peroxidation-dependent necrosis, which is …

New findings necessitate a paradigm shift in our understanding of acute pancreatitis. Intra-
acinar trypsinogen activation leads to early pancreatic injury, but the inflammatory response …

Cytosolic Ca2+ signals are crucial for the control of fluid and enzyme secretion from
exocrine glands. The highly polarized exocrine acinar cells have evolved sophisticated and …