[HTML][HTML] MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer
NG Nickols, R Nazarian, SG Zhao, V Tan… - Prostate cancer and …, 2019 - nature.com
Background Metastatic castration resistant prostate cancer (mCRPC) is incurable and
progression after drugs that target the androgen receptor-signaling axis is inevitable. Thus …
progression after drugs that target the androgen receptor-signaling axis is inevitable. Thus …
[HTML][HTML] EPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells
The EPHB4 receptor is implicated in the development of several epithelial tumors and is a
promising therapeutic target, including in prostate tumors in which EPHB4 is overexpressed …
promising therapeutic target, including in prostate tumors in which EPHB4 is overexpressed …
Privileged 1, 2, 4-oxadiazoles in anticancer drug design: Novel 5-aryloxymethyl-1, 2, 4-oxadiazole leads for prostate cancer therapy
A Lukin, R Karapetian, Y Ivanenkov… - Letters in Drug Design …, 2016 - ingentaconnect.com
Based on the structure of the previously identified leads, new series of compounds
containing 1, 2, 4-oxadiazole core was designed. A small, diverse library of 51 compounds …
containing 1, 2, 4-oxadiazole core was designed. A small, diverse library of 51 compounds …
Driven to metastasize: Kinases as potential therapeutic targets in prostate cancer
Metastatic castration-resistant prostate cancer (mCRPC) is currently a lethal disease.
Although several treatment approaches, including second-generation antiandrogens or …
Although several treatment approaches, including second-generation antiandrogens or …
Allosteric Proteins and Drug Discovery
JE Bell, JK Bell - Burger's Medicinal Chemistry and Drug …, 2003 - Wiley Online Library
The existence of allosteric phenomena in the control of proteins allows for exquisite control
of many of the cell's normal processes. Allosteric interactions involve the binding of an …
of many of the cell's normal processes. Allosteric interactions involve the binding of an …
Allosterism and Drug Discovery
JE Bell, JK Bell - Burger's Medicinal Chemistry and Drug …, 2003 - Wiley Online Library
Interest in allostery and drug development has significantly expanded with increasingly
broad ranges of targets and diseases. Experimental and computational approaches have …
broad ranges of targets and diseases. Experimental and computational approaches have …