Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and
apoptosis, pyroptosis has unique characteristics in morphology and mechanism …

The nod-like receptor family pyrin domain containing 3 (NLRP3) is currently the most widely
studied inflammasome and has become a hot topic of recent research. As a macromolecular …

Chronic heart failure is a clinical syndrome with multiple etiologies, associated with
significant morbidity and mortality. Cardiac arrhythmias, including ventricular …

Background and Objectives: Enhanced beat-to-beat variability of ventricular repolarization
(BVR) has been linked to arrhythmias and sudden cardiac death. Recent experimental …

Rationale: Ventricular arrhythmias often arise from the Purkinje–myocyte junction and are a
leading cause of sudden cardiac death. Notch activation reprograms cardiac myocytes to an …

Intracellular Ca2+ overload, prolongation of the action potential duration (APD), and
downregulation of inward rectifier potassium (IK1) channel are hallmarks of electrical …

β2-Spectrin is critical for integrating membrane and cytoskeletal domains in excitable and
nonexcitable cells. The role of β2-spectrin for vertebrate function is illustrated by dysfunction …

Plasma membrane calcium ATPase 1 (PMCA1, Atp2b1) is emerging as a key contributor to
cardiac physiology, involved in calcium handling and myocardial signalling. In addition …

In addition to beat-to-beat fluctuations, action potential duration (APD) oscillates at (1) a
respiratory frequency and (2) a low frequency (LF)(< 0.1 Hz), probably caused by bursts of …