In 2014, we proposed that orexin signaling transformed motivationally relevant states into
adaptive behavior directed toward exploiting an opportunity or managing a threat, a process …

It has been proposed that binge eating reflects a pathological compulsion driven by the
“addictive” properties of foods. Proponents of this argument highlight the large degree of …

The orexin (hypocretin) system plays a critical role in motivated drug taking. Cocaine self‐
administration with the intermittent access (IntA) procedure produces a robust addiction‐like …

Brain development is a life-long process that encompasses several critical periods of
transition, during which significant cognitive changes occur. Embryonic development …

Orexin, also known as hypocretin, is an excitatory neuropeptide secreted by the
hypothalamus. Orexin is divided into orexin-A (OXA) and orexin-B (OXB), which are derived …

Zebrafish are increasingly being utilized to model the behavioral and neurochemical effects
of pharmaceuticals and, more recently, pharmaceutical interactions. Zebrafish models of …

Behavioral models are central to behavioral neuroscience. To study the neural mechanisms
of maladaptive behaviors (including binge eating and drug addiction), it is essential to …

The orexin (also known as hypocretin) system, consisting of neuropeptides orexin‐A and
orexin‐B, was discovered over 25 years ago and was immediately identified as a central …

Abstract An estimated 50–90% of individuals with cocaine use disorder (CUD) also report
using alcohol. Cocaine users report coabusing alcohol to 'self-medicate'against the negative …

The objective of this work was to determine whether folic acid (FA) reduces the embryonic
ethanol (EtOH) exposure induced behavioral and morphological defects in our zebrafish …