The significance of plasma protein binding on drug efficacy and, subsequently, the clinical
relevance of changes in protein binding has been controversially discussed for decades …

Inhaled corticosteroids (ICS) are the most effective controllers of asthma. They suppress
inflammation mainly by switching off multiple activated inflammatory genes through …

Asthma is a chronic inflammatory disease that affects about 300 million people worldwide, a
total that is expected to rise to about 400 million over the next 15–20 years. Most asthmatic …

Prediction of the air-particle dynamics in human lungs can reveal critical deposition sites of
toxins or can determine best physical parameters for direct drug delivery and associated …

Inhaled glucocorticoids (GCs) are drugs widely used as treatment for asthma patients. They
prevent the recruitment and activation of lung immune and inflammatory cells and …

Glucocorticoids are widely used to treat various inflammatory lung diseases. Acting via the
glucocorticoid receptor (GR), they exert clinical effects predominantly by modulating gene …

Asthma is a chronic inflammatory disease characterized by symptoms of cough, dyspnea,
chest tightness, and wheeze. Inhaled corticosteroids (ICS) have been recommended as …

Inhaled corticosteroid (ICS) therapy in combination with long-acting β-adrenergic agonists
represents the most important treatment for chronic airways diseases such as asthma and …

Dosimetry, safety and the efficacy of drugs in the lungs are critical factors in the development
of inhaled medicines. This article considers the challenges in each of these areas with …

Glucocorticoids are the most effective anti-inflammatory treatment for allergic diseases, and
inhaled glucocorticoids have now become the first-line treatment for asthma. Glucocorticoids …