Diet as a whole, encompassing food composition, calorie intake, and the length and
frequency of fasting periods, affects the time span in which health and functional capacity …

Background The liver is a key regulator of systemic energy homeostasis and can sense and
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …

Omnivores, including rodents and humans, compose their diets from a wide variety of
potential foods. Beyond the guidance of a few basic orosensory biases such as attraction to …

Despite the large volume and extensive range of obesity research, there is substantial
disagreement on the causes and effective preventative strategies. We suggest the field will …

Objective Glucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1RA) and fibroblast
growth factor-21 (FGF21) confer similar metabolic benefits. GLP-1RA induce FGF21, leading …

Adipokines provide an outstanding role in the comprehensive etiology of obesity and may
link adipose tissue dysfunction to further metabolic and cardiovascular complications …

This comprehensive narrative review explores the concept of neuro-vulnerability in energy
metabolism regulation and its implications for metabolic disorders. The review highlights the …

Background Fibroblast growth factor 21 (FGF21) is a hepatokine that produces metabolic
benefits, such as improvements of lipid profile. We performed a genome-wide association …

Summary Fibroblast growth factor 21 (FGF21), an endocrine signal robustly increased by
protein restriction independently of an animal's energy status, exerts profound effects on …

Objective The protein leverage hypothesis (PLH) postulates that strong regulation of protein
intake drives energy overconsumption and obesity when human diets are diluted by fat and …