[HTML][HTML] Nutrition, longevity and disease: From molecular mechanisms to interventions
VD Longo, RM Anderson - Cell, 2022 - cell.com
Diet as a whole, encompassing food composition, calorie intake, and the length and
frequency of fasting periods, affects the time span in which health and functional capacity …
frequency of fasting periods, affects the time span in which health and functional capacity …
[HTML][HTML] Hepatokines and metabolism: Deciphering communication from the liver
SO Jensen-Cody, MJ Potthoff - Molecular metabolism, 2021 - Elsevier
Background The liver is a key regulator of systemic energy homeostasis and can sense and
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …
[HTML][HTML] Learning of food preferences: mechanisms and implications for obesity & metabolic diseases
HR Berthoud, CD Morrison, K Ackroff… - International Journal of …, 2021 - nature.com
Omnivores, including rodents and humans, compose their diets from a wide variety of
potential foods. Beyond the guidance of a few basic orosensory biases such as attraction to …
potential foods. Beyond the guidance of a few basic orosensory biases such as attraction to …
Protein appetite as an integrator in the obesity system: the protein leverage hypothesis
D Raubenheimer, SJ Simpson - … Transactions of the …, 2023 - royalsocietypublishing.org
Despite the large volume and extensive range of obesity research, there is substantial
disagreement on the causes and effective preventative strategies. We suggest the field will …
disagreement on the causes and effective preventative strategies. We suggest the field will …
[HTML][HTML] Fibroblast growth factor-21 is required for weight loss induced by the glucagon-like peptide-1 receptor agonist liraglutide in male mice fed high carbohydrate …
Objective Glucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1RA) and fibroblast
growth factor-21 (FGF21) confer similar metabolic benefits. GLP-1RA induce FGF21, leading …
growth factor-21 (FGF21) confer similar metabolic benefits. GLP-1RA induce FGF21, leading …
[HTML][HTML] Adipokines as clinically relevant therapeutic targets in obesity
M Würfel, M Blüher, M Stumvoll, T Ebert, P Kovacs… - Biomedicines, 2023 - mdpi.com
Adipokines provide an outstanding role in the comprehensive etiology of obesity and may
link adipose tissue dysfunction to further metabolic and cardiovascular complications …
link adipose tissue dysfunction to further metabolic and cardiovascular complications …
[HTML][HTML] Neuro-Vulnerability in Energy Metabolism Regulation: A Comprehensive Narrative Review
VJ Clemente-Suárez, AI Beltrán-Velasco… - Nutrients, 2023 - mdpi.com
This comprehensive narrative review explores the concept of neuro-vulnerability in energy
metabolism regulation and its implications for metabolic disorders. The review highlights the …
metabolism regulation and its implications for metabolic disorders. The review highlights the …
[HTML][HTML] Genome-wide association and Mendelian randomization study of fibroblast growth factor 21 reveals causal associations with hyperlipidemia and possibly …
SC Larsson, K Michaëlsson, M Mola-Caminal, J Höijer… - Metabolism, 2022 - Elsevier
Background Fibroblast growth factor 21 (FGF21) is a hepatokine that produces metabolic
benefits, such as improvements of lipid profile. We performed a genome-wide association …
benefits, such as improvements of lipid profile. We performed a genome-wide association …
[HTML][HTML] Toward reconciling the roles of FGF21 in protein appetite, sweet preference, and energy expenditure
Summary Fibroblast growth factor 21 (FGF21), an endocrine signal robustly increased by
protein restriction independently of an animal's energy status, exerts profound effects on …
protein restriction independently of an animal's energy status, exerts profound effects on …
Macronutrient (im) balance drives energy intake in an obesogenic food environment: An ecological analysis
Objective The protein leverage hypothesis (PLH) postulates that strong regulation of protein
intake drives energy overconsumption and obesity when human diets are diluted by fat and …
intake drives energy overconsumption and obesity when human diets are diluted by fat and …