This review of leukotrienes, which are lipid mediators with a broad array of clinical effects,
and leukotriene receptors considers the biochemical and physiological aspects of these …

BACKGROUND: The goals of asthma treatment include preventing recurrent exacerbations.
Yet there is no consensus about the terminology for describing or defining “exacerbation” or …

Background: The assessment of asthma control is pivotal to the evaluation of treatment
response in individuals and in clinical trials. Previously, asthma control, severity, and …

Importance In asthma and other diseases, vitamin D insufficiency is associated with adverse
outcomes. It is not known if supplementing inhaled corticosteroids with oral vitamin D 3 …

Background The response to treatment for asthma is characterized by wide interindividual
variability, with a significant number of patients who have no response. We hypothesized …

Bronchial asthma is a common inflammatory disease caused by the interaction of genetic
and environmental factors,. Through a genome-wide association study and a replication …

abstract Adult bronchial asthma is characterized by chronic airway inflammation, and
presents clinically with variable airway narrowing (wheezes and dyspnea) and cough. Long …

Background Anti‐leukotrienes (5‐lipoxygenase inhibitors and leukotriene receptors
antagonists) serve as alternative monotherapy to inhaled corticosteroids (ICS) in the …

Asthma is a chronic inflammatory respiratory disease that affects over 300 million people
worldwide. Glucocorticoids are a mainstay therapy for asthma because they exert anti …

Background In asthmatic patients inadequately controlled on inhaled corticosteroids and/or
those with moderate persistent asthma, two main options are recommended: the …